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In this study, selected postmortem hair samples (<jats:italic>n<\/jats:italic>\u2009=\u20091203) from 2008 to 2020 were reanalyzed for synthetic cathinones, piperazines, phenethylamines, hallucinogens, benzodiazepines and opioids to evaluate prevalence data and concentration ranges. Hair samples were extracted using a two\u2010step extraction procedure and analyzed using a validated liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS) method. Overall NPSs were detected in 381 cases (31.6%). Many cases were tested positive for more than one NPS in the same time span. A variety of NPS with a large range of concentrations was observed. For better comparability and interpretation of positive cases in routine work, quantitation data for 13 NPS were calculated as percentiles. The most frequently detected NPS in this study were <jats:italic>N\u2010<\/jats:italic>ethylamphetamine, \u03b1\u2010pyrrolidinovalerophenone, mephedrone, benzedrone, metamfepramone, and 4\u2010fluoroamphetamine. In conclusion, a high prevalence of these drugs was observed from postmortem hair samples. The results show a growing use of many different NPSs by mainly young drug\u2010using adults. Consequently, NPS screening procedures should be included in forensic toxicology. Our quantitative data may support other toxicologists in their assessment of NPS hair concentrations.<\/jats:p>","DOI":"10.1002\/dta.3150","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T06:54:37Z","timestamp":1629960877000},"page":"110-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prevalence and concentrations of new designer stimulants, synthetic opioids, benzodiazepines, and hallucinogens in postmortem hair samples: A 13\u2010year retrospective study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2813-1187","authenticated-orcid":false,"given":"Andr\u00e9","family":"Niebel","sequence":"first","affiliation":[{"name":"Institute of Forensic Medicine Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Institute of Pharmacy, Pharmaceutical Chemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Westendorf","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Krumbiegel","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Hartwig","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7407-8300","authenticated-orcid":false,"given":"Maria Kristina","family":"Parr","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Chemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tsokos","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1365"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-011-0193-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2019.02.040"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.10.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5AN00797F"},{"key":"e_1_2_9_7_1","unstructured":"Federal Ministry of Justice and Consumer Protection and Federal Office of Justice.New psychoactive substance act of 21 November 2016 (BGBl. 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