{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:46:34Z","timestamp":1770518794790,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many jurisdictions use point\u2010of\u2010collection (POC) oral fluid testing devices to identify driving under the influence of cannabis, indexed by the presence of \u0394<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol (THC), an intoxicating cannabinoid, in oral fluid. Although the use of the non\u2010intoxicating cannabinoid, cannabidiol (CBD), is not prohibited among drivers, it is unclear whether these devices can reliably distinguish between CBD and THC, which have similar chemical structures. This study determined whether orally administered CBD produces false\u2010positive tests for THC on standard, POC oral fluid testing devices. In a randomised, double\u2010blind, crossover design, healthy participants (<jats:italic>n<\/jats:italic>\u2009=\u200917) completed four treatment sessions involving the administration of either placebo or 15\u2010, 300\u2010 or 1500\u2010mg pure CBD in a high\u2010fat dietary supplement. Oral fluid was sampled, and the DrugWipe\u00ae\u20105S (DW\u20105S; 10\u2009ng\u00b7ml<jats:sup>\u22121<\/jats:sup> THC cut\u2010off) and Drug Test\u00ae 5000 (DT5000; 10\u2009ng\u00b7mL<jats:sup>\u22121<\/jats:sup> THC cut\u2010off) devices administered, at baseline (pretreatment) and ~20\u2010, ~145\u2010 and ~185\u2010min posttreatment. Oral fluid cannabinoid concentrations were measured using ultra\u2010high performance liquid chromatography\u2013tandem mass spectrometry. Median (interquartile range [IQR]) oral fluid CBD concentrations were highest at ~20\u2009min, quantified as 0.4 (6.0), 15.8 (41.6) and 167 (233) ng\u00b7ml<jats:sup>\u22121<\/jats:sup> on the 15\u2010, 300\u2010 and 1500\u2010mg CBD treatments, respectively. THC, cannabinol and cannabigerol were not detected in any samples. A total of 259 DW\u20105S and 256 DT5000 tests were successfully completed, and no THC\u2010positive tests were observed. Orally administered CBD does not appear to produce false\u2010positive (or true\u2010positive) tests for THC on the DW\u20105S and DT5000. The likelihood of an individual who is using a CBD (only) oral formulation being falsely accused of DUIC therefore appears low.<\/jats:p>","DOI":"10.1002\/dta.3153","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T18:12:28Z","timestamp":1629396748000},"page":"137-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Orally administered cannabidiol does not produce false\u2010positive tests for \u0394<sup>9<\/sup>\u2010tetrahydrocannabinol on the Securetec DrugWipe\u00ae 5S or Dr\u00e4ger DrugTest\u00ae 5000"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-5220","authenticated-orcid":false,"given":"Danielle","family":"McCartney","sequence":"first","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics University of Sydney  Sydney New South Wales Australia"},{"name":"Brain and Mind Centre University of Sydney  Sydney New 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Australia"},{"name":"Faculty of Medicine and Health, Central Clinical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla M.","family":"Hoyos","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre University of Sydney  Sydney New South Wales Australia"},{"name":"Faculty of Science, School of Psychology University of Sydney  Sydney New South Wales Australia"},{"name":"Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain S.","family":"McGregor","sequence":"additional","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics University of Sydney  Sydney New South Wales Australia"},{"name":"Brain and Mind Centre University of Sydney  Sydney New South Wales Australia"},{"name":"Faculty of Science, School of Psychology University of 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