{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T08:29:58Z","timestamp":1769848198441,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Benzodiazepines are a class of compounds used clinically to treat a variety of conditions including anxiety and insomnia. Their potential for abuse has led to a surge in their availability on the illegal drugs market. End users often rely on markings on illicit tablets to identify their contents. However, falsified tablets mimicking genuine pharmaceutical preparations often contain ingredients that differ from what people believe they are taking. The absence of any quality control of the content, purity, or strength of fake tablets can result in adverse effects or even fatal outcomes. In recent years, drug seizures involving illicit round yellow tablets marked \u201c5\u201d on one side and \u201c5617\u201d below a scoreline on the reverse have been submitted to Forensic Science Ireland (FSI) by An Garda S\u00edoch\u00e1na (Irish Police) from throughout the Republic of Ireland. These findings relate to 26 different seizures; the cumulative tablet total seized was in excess of 20,000, and the total number of tablets of this description analyzed at FSI was 141. Irish users assume that the active ingredient present was diazepam. The qualitative analytical results for these tablets are reported. All tablets were found to contain 2\u2010methylamino\u20105\u2010chlorobenzophenone. In addition, the tablets contained either 2\u2010amino\u20103\u2010(2\u2010chlorobenzoyl)\u20105\u2010ethylthiophene or etizolam or both. The constituents were present in varying relative amounts in visually similar tablets. Neither 2\u2010amino\u20105\u2010chlorobenzophenone nor 2\u2010amino\u20103\u2010(2\u2010chlorobenzoyl)\u20105\u2010ethylthiophene had previously been found in tablets analyzed at FSI.<\/jats:p>","DOI":"10.1002\/dta.3204","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:53:18Z","timestamp":1637887998000},"page":"531-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An unusual detection of 2\u2010amino\u20103\u2010(2\u2010chlorobenzoyl)\u20105\u2010ethylthiophene and 2\u2010methylamino\u20105\u2010chlorobenzophenone in illicit yellow etizolam tablets marked \u201c5617\u201d seized in the Republic of Ireland"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1296-3774","authenticated-orcid":false,"given":"Carol","family":"Downey","sequence":"first","affiliation":[{"name":"Forensic Science Ireland  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Forensic Science Ireland  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2496-8396","authenticated-orcid":false,"given":"Gavin","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Forensic Science Ireland  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Forensic Science Ireland  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"O'Brien","sequence":"additional","affiliation":[{"name":"School of Chemistry Trinity College Dublin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1613-3305","authenticated-orcid":false,"given":"Pierce V.","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, School of Medicine Trinity College  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction.New benzodiazepines in Europe \u2013 a review. Publications Office of the European Union Luxembourg.2021https:\/\/www.emcdda.europa.eu\/publications\/technical-reports\/new-benzodiazepines-europe-review_en"},{"key":"e_1_2_8_3_1","unstructured":"Forensic Science Ireland annual report 2016. Accessed October 2021.https:\/\/forensicscience.ie\/documents\/FSI%20Annual%20Report%202016.pdf"},{"key":"e_1_2_8_4_1","unstructured":"DuffinT KeaneM MillarSR.Street tablet use in Ireland: a trendspotter study on use markets and harms. ANA Liffey Drug Project Dublin.2020. Accessed October 2021.https:\/\/www.aldp.ie\/content\/uploads\/2020\/04\/Trendspotter\u2010Report_Street\u2010Tablets\u2010Ireland_FINAL\u201021.04.20.pdf"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14060560"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2211"},{"key":"e_1_2_8_7_1","unstructured":"International Narcotics Control Board.List of psychotropic substances under international control 2020. Accessed October 2021.https:\/\/www.incb.org\/documents\/Psychotropics\/forms\/greenlist\/Green_list_ENG_V20_03594.pdf"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dar.13052"},{"issue":"7","key":"e_1_2_8_9_1","first-page":"970","article-title":"The emergence of new psychoactive substance (NPS) benzodiazepines. A survey of their prevalence in opioid substitution patients using LC\u2010MS","volume":"112","author":"McNamara S","year":"2019","journal-title":"Ir Med J"},{"key":"e_1_2_8_10_1","unstructured":"TICTAC database. Accessed October 2021.https:\/\/www.tictac.org.uk"},{"key":"e_1_2_8_11_1","unstructured":"MedsChat.Yellow round pill 5617 5. Accessed October 2021.https:\/\/www.medschat.com\/Discuss\/Yellow-round-pill-5617-5-334454.htm"},{"key":"e_1_2_8_12_1","unstructured":"MedsChat.Yellow Round Pill 5 5617. 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