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Furthermore, the entire fragmentation pathway of 2\u2010fluorodeschlorohydroxylimine was theorized from the GC\u2013MS spectrum recorded using an electron ionization (EI) source, and the mechanisms and decomposition pathways of 2\u2010fluorodeschlorohydroxylimine were elucidated. In protic solvents, the nitrogen atom in the C\u2550N group of 2\u2010fluorodeschlorohydroxylimine underwent a protonation reaction. Thereafter, the traces of water present in protic solvents promoted the hydrolysis of the protonated imine, and a carbon cation was obtained following the loss of methylamine. The carbon cation could follow the classical decomposition mechanism of imines and yield an \u03b1\u2010hydroxyl ketone, which was the major decomposition product, (2\u2032\u2010fluorophenyl)(1\u2033\u2010hydroxycyclopentyl)methanone. The cation could also undergo a loop expansion rearrangement and yield another \u03b1\u2010hydroxyl ketone, 2\u2010(2\u2032\u2010fluorophenyl)\u20102\u2010hydroxycyclohexan\u20101\u2010one. The structures of the two aforementioned decomposition products were elucidated using several techniques including theoretical calculation, GC\u2013MS, nuclear magnetic resonance (NMR), the prediction and assistance elucidation functions of ACDLabs\u2010Structure Elucidator Suite, and the virtual separation technology of diffusion\u2010ordered spectroscopy. The aforementioned study revealed important information about the chemical precursor of 2\u2010FDCK and its decomposition. Furthermore, a set of methods for the qualitative analysis of 2\u2010fluorodeschlorohydroxylimine were established, which facilitated accurate analysis of 2\u2010fluorodeschlorohydroxylimine samples following decomposition or destruction.<\/jats:p>","DOI":"10.1002\/dta.3229","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T21:59:20Z","timestamp":1643320760000},"page":"1065-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Structure identification and analysis of the suspected chemical precursor of 2\u2010fluorodeschloroketamine and its decomposition products"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7923-7817","authenticated-orcid":false,"given":"Xuan","family":"Luo","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guangxi University  Nanning China"},{"name":"Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development Guangxi University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guangxi University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiulian","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guangxi University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejian","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Forensic Science Public Security Department of Guangxi  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Forensic Science Public Security Department of Guangxi  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Forensic Science Public Security Department of Guangxi  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzeng","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guangxi University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunli","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guangxi University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbo","family":"Li","sequence":"additional","affiliation":[{"name":"Anti\u2010drug Detachment Public Security Bureau of Nanning  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"21st List, 2019","author":"World Health Organization Model List of Essential Medicines","year":"2019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt196563279"},{"key":"e_1_2_7_4_1","unstructured":"United Nations Office on Drugs and Crime.World drug report 2019. 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