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Thebaine is an opium alkaloid that has been shown to be present in the urine of individuals who have consumed poppy seeds, as well as those who have used opium. It is not present in heroin. We present a sensitive, specific liquid chromatography tandem mass spectrometry (LC\u2013MS\/MS) assay for thebaine. We show that thebaine is detectable after consumption of two different poppy seed\u2010containing products for up to 72\u2009h in urine. We discuss limitations of the assay and suggest how the test might best be used.<\/jats:p>","DOI":"10.1002\/dta.3274","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T21:03:50Z","timestamp":1651093430000},"page":"1539-1546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Urine thebaine determination by liquid chromatography tandem mass spectrometry after poppy seed consumption"],"prefix":"10.1002","volume":"14","author":[{"given":"Stephanie Marina","family":"Bollini","sequence":"first","affiliation":[{"name":"Truetox Laboratories, LLC  New Hyde Park New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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