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In December 2021, eight capsules were submitted to ChemCentre for analysis. The samples were analysed by a range of analytical techniques including gas chromatography\u2013mass spectrometry (GC\u2013MS), ultraviolet\u2013visible spectrophotometry, liquid chromatography\u2010mass spectrometry (LC\u2013MS, low and high resolution), nuclear magnetic resonance (NMR) spectroscopy and X\u2010ray crystallography, which identified the main component of the capsules to be 4\u2032\u2010chloro deschloroalprazolam, a new designer benzodiazepine. Alarmingly, the mass spectral data for this alprazolam analogue were very similar to that of alprazolam, such that misidentification could be possible. A minor component of the capsules was also partially characterised, it is believed to be the synthetic precursor 4\u2032\u2010chloro deschloronordiazepam. The information provided in this paper includes ways to discriminate these analogues from alprazolam and nordiazepam which will enable other laboratories to identify these new drugs.<\/jats:p>","DOI":"10.1002\/dta.3325","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T21:25:10Z","timestamp":1654291510000},"page":"1672-1680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The alprazolam analogue 4\u2032\u2010chloro deschloroalprazolam identified in seized capsules"],"prefix":"10.1002","volume":"14","author":[{"given":"Sheena","family":"Trigg","sequence":"first","affiliation":[{"name":"Forensic Science Laboratory ChemCentre  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Wells","sequence":"additional","affiliation":[{"name":"Forensic Science Laboratory ChemCentre  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-0584","authenticated-orcid":false,"given":"Jasmine","family":"McGann","sequence":"additional","affiliation":[{"name":"Forensic Science Laboratory ChemCentre  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soeren","family":"Bock","sequence":"additional","affiliation":[{"name":"Forensic Science Laboratory ChemCentre  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Holman","sequence":"additional","affiliation":[{"name":"Forensic Science Laboratory ChemCentre  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Forensic Science Laboratory ChemCentre  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching Yong","family":"Goh","sequence":"additional","affiliation":[{"name":"School of Molecular and Life Sciences Curtin University  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5339-7070","authenticated-orcid":false,"given":"Stephen A.","family":"Moggach","sequence":"additional","affiliation":[{"name":"School of Molecular Sciences University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2270-9681","authenticated-orcid":false,"given":"David H.","family":"Brown","sequence":"additional","affiliation":[{"name":"Forensic Science Laboratory ChemCentre  Bentley Western Australia Australia"},{"name":"School of Molecular and Life Sciences Curtin University  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.15816"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yco.0000165594.60434.84"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2018_154"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4140\/TCP.n.2013.538"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0740\u20105472(91)90027\u20108"},{"key":"e_1_2_7_7_1","unstructured":"MarinMJ vanWijkXMR.The evolution of designer benzodiazepines: challenges for detection and monitoring.Clinical Laboratory News: Washington DC 2019.https:\/\/www.aacc.org\/cln\/articles\/2019\/november\/the-evolution-of-designer-benzodiazepinesAccessed February 20 2022."},{"key":"e_1_2_7_8_1","unstructured":"Australian Criminal Intelligence Commission (ACIC).Illicit Drug data report 2019\u201320.https:\/\/www.acic.gov.au\/sites\/default\/files\/2021-10\/IDDR%202019-20_271021_Full_0.pdf. 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