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Thus, the interaction between nicotine e\u2010liquids and DOTNs must be evaluated. Presented is the change in e\u2010cigarette aerosolization of nicotine and methadone alone versus a 1:1 nicotine:methadone mixture to evaluate the possible formation of a eutectic mixture that can result in an increase of drug delivery. E\u2010liquids were prepared in\u2010house using 1:1 propylene glycol (PG):vegetable glycerin (VG) as a base plus nicotine, methadone hydrochloride, or 1:1 nicotine:methadone hydrochloride. The e\u2010liquids were aerosolized via an automated vaping machine using parameters adopted from the Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) E\u2010cigarette Task Force method. Drug recovery was determined by capturing the aerosol from 15 puffs generated by the e\u2010cigarette. Concentrations of nicotine and methadone aerosolized were determined by gas chromatography\u2013mass spectrometry using nicotine (<jats:italic>n<\/jats:italic>\u2009=\u20093), methadone (<jats:italic>n<\/jats:italic>\u2009=\u20093), and combined nicotine\/methadone e\u2010liquids (<jats:italic>n<\/jats:italic>\u2009=\u20093), each prepared in\u2010house at 12\u2009mg\/ml. The concentration of nicotine and methadone in 15 puffs of the single drug e\u2010liquids were determined to be 1.60\u2009\u00b1\u20090.20 and 2.67\u2009\u00b1\u20090.12\u2009mg, respectively. The concentration of nicotine and methadone in 15 puffs of the multidrug e\u2010liquid were determined to be 3.66\u2009\u00b1\u20090.49 and 3.65\u2009\u00b1\u20090.10\u00a0mg, respectively. The single nicotine and methadone e\u2010liquids had recoveries of 70\u2009\u00b1\u20090.1% and 84\u2009\u00b1\u20090.1%, respectively. In the 1:1 mixture, the recovery of both drugs increased. The development of a eutectic mixture can promote aerosolization of the drug and deliver a greater dose to the user.<\/jats:p>","DOI":"10.1002\/dta.3343","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:52:36Z","timestamp":1658191956000},"page":"1091-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A determination of the aerosolization efficiency of drugs of abuse in a eutectic mixture with nicotine in electronic cigarettes"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-9869","authenticated-orcid":false,"given":"Laerissa","family":"Reveil","sequence":"first","affiliation":[{"name":"Department of Forensic Science Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9757-9255","authenticated-orcid":false,"given":"Adam C.","family":"Pearcy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jazmine","family":"Povlick","sequence":"additional","affiliation":[{"name":"Department of Forensic Science Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5470-5717","authenticated-orcid":false,"given":"Justin L.","family":"Poklis","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9591-3117","authenticated-orcid":false,"given":"Matthew S.","family":"Halquist","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1480-139X","authenticated-orcid":false,"given":"Michelle R.","family":"Peace","sequence":"additional","affiliation":[{"name":"Department of Forensic Science Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntv264"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.05.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntu191"},{"key":"e_1_2_6_5_1","unstructured":"VillarroelMA ChaAE VahratianA.Electronic cigarette use among U.S. adults 2018.2020. 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