{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:46:25Z","timestamp":1787168785279,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adherence to therapy is the key to a successful therapeutic intervention, especially in cardiovascular diseases in which a lack of adherence may have serious consequences in terms morbidity and\/or mortality. In this context, hair analysis can be an excellent tool to monitor adherence to therapy. Indeed, drugs present in blood are incorporated into the hair matrix, where drugs and metabolites can stay unaltered for a long time protected from metabolism and degradation. In the present study, a simple, specific, and sensitive ultra\u2010high performance liquid\u2010chromatography\u2013tandem mass spectrometry (UHPLC\u2010MS\/MS) method set up to determine in human hair seven beta\u2010blockers (viz., metoprolol, sotalol, labetalol, atenolol, nebivolol, bisoprolol, and nadolol) and two calcium\u2010channel blockers (lercanidipine and amlodipine), which are widely prescribed to treat medium\u2010to\u2010severe hypertensive conditions. The optimized method was successfully validated in terms of accuracy, repeatability, reproducibility, matrix effect and extraction recovery. Moreover, the applicability of the method was evaluated by analyzing 34 real samples of hair obtained from patients under long\u2010term therapy with calcium channel blockers and beta\u2010blockers.<\/jats:p>","DOI":"10.1002\/dta.3346","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T02:08:26Z","timestamp":1658282906000},"page":"1773-1778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hair analysis for beta\u2010blockers and calcium\u2010channel blockers by using liquid chromatography\u2010tandem mass spectrometry\u00a0as a tool for monitoring adherence to antihypertensive therapy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4728-6686","authenticated-orcid":false,"given":"Francesco","family":"Taus","sequence":"first","affiliation":[{"name":"Unit of Forensic Medicine, Department of Diagnostics and Public Health University of Verona  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