{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:46:37Z","timestamp":1777916797510,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of novel lysergamides continues to occur, based on both the needs of psychedelic medicine and commercial interest in new recreational substances. The present study continues the authors' research on novel lysergamides and describes the analytical profile of 1\u2010cyclopropanoyl\u2010AL\u2010LAD (IUPAC name: 1\u2010(cyclopropanecarbonyl)\u2010<jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010diethyl\u20106\u2010(prop\u20102\u2010en\u20101\u2010yl)\u20109,10\u2010didehydroergoline\u20108\u03b2\u2010carboxamide; 1cP\u2010AL\u2010LAD), using various chromatographic, mass spectrometric, and spectroscopic methods. Analysis of a powdered sample of 1cP\u2010AL\u2010LAD, obtained from an online vendor, by high performance liquid chromatography\u2010electrospray ionization\u2010quadrupole time\u2010of\u2010flight mass spectrometry in full scan\/AutoMS\/MS mode revealed the detection of 17 impurities based on high\u2010resolution tandem mass spectral data; tentative determination of their identity was based on mass spectral grounds alone, though detection of AL\u2010LAD and 1P\u2010AL\u2010LAD was confirmed using available reference standards. Other tentative compound identifications included 1\u2010acetyl\u2010AL\u2010LAD and several other substances potentially reflecting oxidation of the <jats:italic>N<\/jats:italic><jats:sup>6<\/jats:sup>\u2010allyl group as well as other positions on the ergoline ring system. These data may assist those interested in the chemistry of lysergamides. Finally, 1cP\u2010AL\u2010LAD was also detected in samples of \u201cblotters\u201d sold online for recreational use.<\/jats:p>","DOI":"10.1002\/dta.3397","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T05:23:48Z","timestamp":1667366628000},"page":"277-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Analytical profile of the lysergamide 1cP\u2010AL\u2010LAD and detection of impurities"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1613-3305","authenticated-orcid":false,"given":"Pierce V.","family":"Kavanagh","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, School of Medicine Trinity Centre for Health Sciences, St. James Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0452-7814","authenticated-orcid":false,"given":"Folker","family":"Westphal","sequence":"additional","affiliation":[{"name":"Section Narcotics\/Toxicology State Bureau of Criminal Investigation Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-2111","authenticated-orcid":false,"given":"Benedikt","family":"Pulver","sequence":"additional","affiliation":[{"name":"Section Narcotics\/Toxicology State Bureau of Criminal Investigation Schleswig\u2010Holstein  Kiel Germany"},{"name":"Institute of Forensic Medicine, Forensic Toxicology, Medical Center, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Hermann Staudinger Graduate School University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-5831","authenticated-orcid":false,"given":"Hannes M.","family":"Schwelm","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine, Forensic Toxicology, Medical Center, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Hermann Staudinger Graduate School University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Stratford","sequence":"additional","affiliation":[{"name":"Synex Synthetics BV  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1883-2804","authenticated-orcid":false,"given":"Volker","family":"Auw\u00e4rter","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine, Forensic Toxicology, Medical Center, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-4330","authenticated-orcid":false,"given":"Stephen J.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Isomer Design  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-5829","authenticated-orcid":false,"given":"Adam L.","family":"Halberstadt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"},{"name":"Research Service, VA San Diego Healthcare System  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-5372","authenticated-orcid":false,"given":"Simon D.","family":"Brandt","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences Liverpool John Moores University  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"52","volume-title":"Hallucinogens: An Update. 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