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Driving license regranting is based on the evaluation of medicolegal and toxicological variables that may include serum carbohydrate\u2010deficient transferrin (CDT) and hair ethyl glucuronide (hEtG).<\/jats:p><jats:p>The aim of the study was to compare the diagnostic performance of CDT and hEtG in a population of DUI offenders. Other factors potentially associated with heavy alcohol use were explored. The population included DUI offenders examined during the period of January 1, 2019, through June 30, 2022. Sociodemographic, medicolegal, and toxicological variables were collected. CDT in serum and EtG in head hair were determined in all subjects. Excessive alcohol intake (hEtG \u226530\u2009pg\/mg) was considered cause for unfitness to drive. Cohen's kappa coefficient was calculated. Descriptive analyses were performed using chi\u2010square and Mann\u2013Whitney tests. Variables significantly different between the groups were included in a multivariate binary logistic regression model. The sample encompassed 838 subjects (case group: 179, comparison group: 689). CDT exhibited poor agreement (\u03ba\u2009=\u20090.053) with hEtG as the reference test. Lower education, age at DUI, heavy smoking, and GGT levels associated with heavy alcohol consumption differentiated the two groups. For DUI offenders, the use of CDT to assess heavy alcohol consumption is limited, possibly due to the time\u2010window assessed, the time required for normalization, and the different amount of ethanol needed to reach higher CDT levels, in comparison to hEtG; thus, hEtG assessment is strongly recommended for this population. Heavy smoking, GGT, education, and age could be related to heavy alcohol consumption and higher risk of DUI.<\/jats:p>","DOI":"10.1002\/dta.3426","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T11:34:01Z","timestamp":1671190441000},"page":"953-961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Driving license regranting: Hair EtG, serum CDT, and the role of sociodemographic and medicolegal variables"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-6814","authenticated-orcid":false,"given":"Alessandro","family":"Cinquetti","sequence":"first","affiliation":[{"name":"Legal Medicine and Toxicology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7499-7232","authenticated-orcid":false,"given":"Claudio","family":"Terranova","sequence":"additional","affiliation":[{"name":"Legal Medicine and Toxicology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Aprile","sequence":"additional","affiliation":[{"name":"Legal Medicine and Toxicology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2176-6876","authenticated-orcid":false,"given":"Donata","family":"Favretto","sequence":"additional","affiliation":[{"name":"Legal Medicine and Toxicology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15389588.2014.968656"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6850a1"},{"key":"e_1_2_6_4_1","unstructured":"Drunk Driving|Statistics and Resources|NHTSA.https:\/\/www.nhtsa.gov\/risky-driving\/drunk-driving. 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