{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:48Z","timestamp":1786977708094,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015015","name":"Government of South Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recent research reported that lurasidone degrades in unpreserved ante\u2010mortem human whole blood inoculated with microorganisms known to dominate postmortem blood specimens. In vitro degradation occurred at a similar rate to risperidone, known to degrade in authentic postmortem specimens until below analytical detection limits. To identify the lurasidone degradation products formed, an Agilent 6520 liquid chromatograph quadrupole\u2010time\u2010of\u2010flight mass spectrometer (LC\u2010QTOF\u2010MS) operating in auto\u2010MS\/MS mode was used. Numerous degradation products not previously reported in prior in vitro or in vivo pharmacokinetic studies or forced degradation studies were detected. Accurate mass data, mass fragmentation data, acetylation experiments, and a proposed mechanism of degradation analogous to risperidone supports initial identification of the major degradation product as\n                    <jats:italic>N<\/jats:italic>\n                    \u2010debenzisothiazole\u2010lurasidone (calculated m\/z [M\u2009+\u2009H]\n                    <jats:sup>+<\/jats:sup>\n                    \u2009=\u2009360.2646). A standard was unavailable to conclusively confirm this identification. Retrospective data analysis of postmortem cases involving lurasidone identified the presence of the major degradation product in four of six cases where lurasidone was also detected. This finding is significant for toxicology laboratories screening for this drug in postmortem casework. The major postmortem lurasidone degradation product has consequently been added to the LC\u2010QTOF\u2010MS drug screen at Forensic Science SA (FSSA) to indicate postmortem lurasidone degradation in authentic postmortem blood specimens and as a marker of lurasidone administration in the event lurasidone is degraded to concentrations below detection limits.\n                  <\/jats:p>","DOI":"10.1002\/dta.3441","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T03:42:11Z","timestamp":1673926931000},"page":"551-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Microbial degradation products of lurasidone and their significance in postmortem toxicology"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1959-2873","authenticated-orcid":false,"given":"Jared W.","family":"Castle","sequence":"first","affiliation":[{"name":"College of Science and Engineering Flinders University  Bedford Park South Australia Australia"},{"name":"CSIRO Land &amp; Water, Environmental Contaminant Mitigation and Technologies  Glen Osmond South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M.","family":"Butzbach","sequence":"additional","affiliation":[{"name":"College of Science and Engineering Flinders University  Bedford Park South Australia Australia"},{"name":"Forensic Science SA  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1922-5686","authenticated-orcid":false,"given":"G. Stewart","family":"Walker","sequence":"additional","affiliation":[{"name":"College of Science and Engineering Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-8569","authenticated-orcid":false,"given":"Claire E.","family":"Lenehan","sequence":"additional","affiliation":[{"name":"College of Science and Engineering Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Reith","sequence":"additional","affiliation":[{"name":"CSIRO Land &amp; Water, Environmental Contaminant Mitigation and Technologies  Glen Osmond South Australia Australia"},{"name":"School of Biological Sciences The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-1812","authenticated-orcid":false,"given":"Samuel P.","family":"Costello","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7666-4039","authenticated-orcid":false,"given":"K. Paul","family":"Kirkbride","sequence":"additional","affiliation":[{"name":"College of Science and Engineering Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Sunovion.Latuda (lurasidone HCl) tablets prescribing information.2013.http:\/\/www.latuda.com\/LatudaPrescribingInformation.pdf. Accessed October 3 2020."},{"key":"e_1_2_7_3_1","unstructured":"Therapeutic Goods Administration.Australian public assessment report for lurasidone hydrochloride. Department of Health Australia:2014."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1379989"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000774"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000496"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2017.1388385"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/8755122514533305"},{"key":"e_1_2_7_9_1","first-page":"708","article-title":"Retrospective evaluation of lurasidone ingestions reported to the national poison data system [abstract]","volume":"51","author":"Van Nest KE","year":"2013","journal-title":"Clin Toxicol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2020.1737102"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000224"},{"key":"e_1_2_7_12_1","unstructured":"TabacovaS.Lurasidone pharmacology review. Department of Health and Human Services Public Health Service Food and Drug Administration Center for Drug Evaluation and Research;2009."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/136194"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3059"},{"issue":"3","key":"e_1_2_7_15_1","first-page":"191","article-title":"Lurasidone drug\u2010drug interaction studies: a comprehensive review","volume":"29","author":"Chiu Y\u2010Y","year":"2014","journal-title":"Drug Metab Pers Ther"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000892"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010016\u20100465\u20105"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440\u2010020\u201000102\u20105"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3239"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119062585.ch10"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02096"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS16081J"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkx108"},{"key":"e_1_2_7_24_1","unstructured":"The National Health and Medical Research Council the Australian Research Council and Universities Australia Commonwealth of Australia Canberra.National Statement on Ethical Conduct in Human Research 2007 (Updated 2018). 2007 (Updated 2018).www.nhmrc.gov.au\/guidelines\/publications\/e72"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.11.035"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.4871"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556\u20104029.2012.02280.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1503"},{"issue":"9","key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0090-9556(25)06734-0","article-title":"Application of hyphenated LC\/NMR and LC\/MS techniques in rapid identification of in vitro and in vivo metabolites of iloperidone","volume":"23","author":"Mutlib AE","year":"1995","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1997.tb06790.x"},{"key":"e_1_2_7_31_1","unstructured":"ButzbachDM.The stability of selected psychiatric medications during simulated post\u2010mortem decomposition[PhD thesis]. 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