{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:16:16Z","timestamp":1786947376650,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The disappearance of drug from hair does not occur immediately after abstinence because dormant hair may contribute to the positivity of freshly grown hair. The aim of this study was to assess ketamine disappearance from hair after treatment cessation and to review the literature data. A 22\u2010year\u2010old female received three intravenous doses of ketamine (171\u2009mg) for major depression treatment. Seventeen weeks later, a 26\u2009cm lock of hair was sampled, and ketamine was determined by liquid chromatography tandem mass spectrometry (LC\u2013MS\/MS)\u00a0on seven segments: A (proximal, 0\u20132\u00a0cm), B (2\u20134\u00a0cm), C (4\u20136\u00a0cm, period of ketamine therapy), and D to G (4\u2009\u00d7\u20095\u2009cm). Ketamine concentration was 58\u2009pg\/mg in Segment C and remained detectable over 4\u00a0months after treatment cessation at 67\u2009pg\/mg in Segment B and 2\u00a0pg\/mg in Segment A, representing a 97% drop from the initial concentration. Ketamine elimination half\u2010life in hair was estimated at 0.88\u2009month, implying that indetectable concentration should be expected 7\u2009months after cessation. Axial diffusion was excluded as ketamine was not detected in Segments D\u2013G. Given the low ketamine concentrations, norketamine was not detected. While no data on ketamine disappearance from hair have been published to date, previous studies have shown that discontinuation resulted in negative hair results after 3\u00a0months for heroin, 3\u20134\u00a0months for cocaine and tramadol, 6\u00a0months for amphetamine and methamphetamine, and 6\u20137\u00a0months for THC\u2010COOH. This study provides useful findings for ketamine hair concentration interpretation, which should be validated by more consistent and comprehensive investigations.<\/jats:p>","DOI":"10.1002\/dta.3444","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T18:48:35Z","timestamp":1674240515000},"page":"971-979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The duration of ketamine detection in hair after treatment cessation: Case study and review of the literature in forensic and clinical casework"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-5342","authenticated-orcid":false,"given":"I.\u2010A.","family":"Larabi","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Raymond Poincar\u00e9 hospital, AP\u2010HP  Garches France"},{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm U1018, CESP, \u00c9quipe MOODS  Montigny\u2010le\u2010Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Etting","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Raymond Poincar\u00e9 hospital, AP\u2010HP  Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5344-9475","authenticated-orcid":false,"given":"J.\u2010C.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Raymond Poincar\u00e9 hospital, AP\u2010HP  Garches France"},{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm U1018, CESP, \u00c9quipe MOODS  Montigny\u2010le\u2010Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.06.011"},{"key":"e_1_2_6_3_1","volume-title":"Hair Analysis in Clinical and Forensic Toxicology","author":"Kintz P","year":"2015"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0379\u20100738(93)90280\u2010N"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004140050056"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0379\u20100738(96)02047\u20106"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.11.1846"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1607"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bku106"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2009.04.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.276"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.10.024"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.02.019"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.09.113"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2012.10.028"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2015.06.030"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2018.01.011"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkz004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414\u2010010\u20100534\u20105"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2012.12.013"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkaa166"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2016.03.010"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/29.5.314"},{"key":"e_1_2_6_24_1","unstructured":"2021 SoHT consensus on drugs of abuse (DoA) testing in hair.Society of Hair Testing (SoHT); 2021. 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