{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:58Z","timestamp":1786977598221,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hematological parameters and erythropoiesis are known to be influenced by anabolic androgenic steroid (AAS) use. However, little is known in relation to supra\u2010physiological doses of AAS. Therefore, the aim of this study was to evaluate the effect of supra\u2010physiological doses of AAS on serum and urinary erythropoietin (EPO), and blood parameters, from self\u2010reported AAS users. Serum EPO levels were higher in testosterone positive AAS users (11.83\u2009mIU\/mL\u2009\u00b1\u20094.19) than nonpositive (6.60\u2009mIU\/mL\u2009\u00b1\u20092.70,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), while no differences in urinary EPO levels were noted. There were positive correlations between serum EPO and testosterone levels (rs\u2009=\u20090.46,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) and reticulocyte percentage (rs\u2009=\u20090.43,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). Individuals with AAS\u2010induced hypogonadism (ASIH; luteinizing hormone levels &lt;1.4\u00a0IU\/L) had approximately 75% higher serum EPO (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and 140% higher high fluorescence reticulocyte fractions (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), as well as other affected hematological parameters, compared with non\u2010ASIH individuals. The results extend the knowledge of how endocrine and hematological biomarkers are affected by AAS doping.\n                  <\/jats:p>","DOI":"10.1002\/dta.3452","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T13:04:40Z","timestamp":1675343080000},"page":"599-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Supra\u2010physiological doses of anabolic androgenic steroids impact erythropoietin and blood parameters"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-7364","authenticated-orcid":false,"given":"Carmel E.","family":"Heiland","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Pharmacology, Karolinska University Laboratory Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Schickel","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Lehtihet","sequence":"additional","affiliation":[{"name":"Department of Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0159-7315","authenticated-orcid":false,"given":"Annica","family":"B\u00f6rjesson","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Karolinska University Laboratory Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Neurobiology, Care Sciences, and Society (NVS) Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-2345","authenticated-orcid":false,"given":"Lena","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2185"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11182"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010011\u20101867\u20106"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2665"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000460722"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1932"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3031"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26368"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.02.039"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/frph.2021.787954"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13592"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007\u20101692"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/510257"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP089433"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.12.042"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2341"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2803"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3017"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3202"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2763"},{"key":"e_1_2_5_22_1","unstructured":"WADA.TD2021EAAS: Measurement and Reporting of Endogenous Anabolic Androgenic Steroid (EAAS) Markers of the Urinary Steroid Profile. 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