{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:43:24Z","timestamp":1791434604606,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An 11\u2010month\u2010old boy was found dead. Autopsy findings (cyanosis and polyvisceral congestion) and blood tramadol (TR) concentration of 6240\u2009\u03bcg\/L were consistent with an acute TR intoxication. In this poisoning situation, owing to the mother's statements (TR addiction leading to daily TR\u2010orange juice mixture preparation accidentally used for the baby bottle preparation by the mother's partner), and the question of possible previous TR administrations to the infant, hair and\/or nails (infant, mother, partner, 6\u2010year\u2010old sister) analysis was performed. Hair (2\u2010cm\u2010long hair segments from proximal [S1] to distal [S3]) and nails concentrations (pg\/mg; nd: not detected) were as follows: Infant (hair: TR 1420 [S1], 1622 [S2], 2736 [S3];\n                    <jats:italic>O<\/jats:italic>\n                    \u2010DMT 16\u201338;\n                    <jats:italic>N<\/jats:italic>\n                    \u2010DMT 34\u2013100 [TR in significant quantities in the hair decontamination bath]\u2014toenails: TR 584;\n                    <jats:italic>O<\/jats:italic>\n                    \u2010DMT 8;\n                    <jats:italic>N<\/jats:italic>\n                    \u2010DMT 15), mother (hair: TR 2340 [S1], 2150 [S2], 2500 [S3];\n                    <jats:italic>O<\/jats:italic>\n                    \u2010DMT 704\u20131170;\n                    <jats:italic>N<\/jats:italic>\n                    \u2010DMT 827\u20131360), mother's partner (fingernails: TR 72;\n                    <jats:italic>O<\/jats:italic>\n                    \u2010DMT nd;\n                    <jats:italic>N<\/jats:italic>\n                    \u2010DMT nd) and sister (hair: TR 261 [S1], 524 [S2];\n                    <jats:italic>O<\/jats:italic>\n                    \u2010DMT 15 [S1], 16 [S2];\n                    <jats:italic>N<\/jats:italic>\n                    \u2010DMT 20 [S1], 38 [S2]). Metabolite ratio (infant and sister hair) was comparable to those observed in hair of pharmaceutical industry employees manufacturing tramadol. TR in washing baths, low observed nail concentrations (infant and partner) confirm (i) TR\u2010related mother's addiction and (ii) external contamination issues (TR in sweat of the child at the time of death and in living environment) to explain the infant's keratinized samples results. This case report illustrates the interest of analyzing keratinized matrices of the whole family in such a situation.\n                  <\/jats:p>","DOI":"10.1002\/dta.3485","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T21:50:33Z","timestamp":1682632233000},"page":"1022-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Interpretation of hair and nails findings in an infant death case related to maternal addiction to tramadol"],"prefix":"10.1002","volume":"15","author":[{"given":"Alexandr","family":"Gish","sequence":"first","affiliation":[{"name":"CHU Lille Unit\u00e9 Fonctionnelle de Toxicologie  Lille France"},{"name":"Univ. Lille, URL 4483 \u2013 IMPECS \u2013 IMPact de l'Environnement Chimique sur la Sant\u00e9 humaine  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1234-5167","authenticated-orcid":false,"given":"Camille","family":"Richeval","sequence":"additional","affiliation":[{"name":"CHU Lille Unit\u00e9 Fonctionnelle de Toxicologie  Lille France"},{"name":"Univ. Lille, URL 4483 \u2013 IMPECS \u2013 IMPact de l'Environnement Chimique sur la Sant\u00e9 humaine  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Wiart","sequence":"additional","affiliation":[{"name":"CHU Lille Unit\u00e9 Fonctionnelle de Toxicologie  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Hennart","sequence":"additional","affiliation":[{"name":"CHU Lille Unit\u00e9 Fonctionnelle de Toxicologie  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-6711","authenticated-orcid":false,"given":"Florian","family":"Hakim","sequence":"additional","affiliation":[{"name":"CHU Lille Unit\u00e9 Fonctionnelle de Toxicologie  Lille France"},{"name":"Univ. Lille, URL 4483 \u2013 IMPECS \u2013 IMPact de l'Environnement Chimique sur la Sant\u00e9 humaine  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Demarly","sequence":"additional","affiliation":[{"name":"CHU Lille Service de M\u00e9decine L\u00e9gale  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axelle","family":"Balgairies","sequence":"additional","affiliation":[{"name":"CHU Lille Service de M\u00e9decine L\u00e9gale  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ry","family":"H\u00e9douin","sequence":"additional","affiliation":[{"name":"CHU Lille Service de M\u00e9decine L\u00e9gale  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Allorge","sequence":"additional","affiliation":[{"name":"CHU Lille Unit\u00e9 Fonctionnelle de Toxicologie  Lille France"},{"name":"Univ. 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