{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:17:36Z","timestamp":1790360256671,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The work discusses the results of hair and urine testing performed in 51 cases of suspected in utero drug exposure handled at the University Hospital of Verona from 2016 to 2022. On the day of birth or the day after birth, urine from mother and newborn (UM and UN) and hair from mother (HM), newborn (HN) and father (HF), if possible, were collected. Urine underwent immunoassay and GC\u2013MS analysis, whereas hair underwent LC\u2013MS\/MS and GC\u2013MS\/MS analysis. In 50 out of 51 cases, HM and\/or HN were available. In 92% of them, hair testing resulted in a positive, often (&gt;50% cases) for more than one class of substance. The most detected substances were cocaine, opiates, methadone and cannabinoids. Maternal segmental analysis showed a prevalent decreasing concentration trend during pregnancy in case of positivity for one class of substances, whereas, as expected, a neatly prevalent increasing trend in the case of positivity for more than one class of substances. In nine cases, HF was also available, resulting in all being positive, usually for the same classes of substances identified in HM, thus questioning parental responsibility. In 33 cases, urine samples from the mother or newborn were also collected. Of them, 27 cases (82%) tested positive, showing peri\u2010partum drug consumption and then confirming the severity of the addiction. Hair testing showed to be a reliable diagnostic tool to investigate in utero drug exposure because of the possibility of obtaining a complete picture of maternal addictive behaviour and family background, thanks to segmental maternal hair analysis and father hair testing.<\/jats:p>","DOI":"10.1002\/dta.3515","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T05:23:45Z","timestamp":1683523425000},"page":"980-986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hair testing applied to the assessment of in utero exposure to drugs: Critical analysis of 51 cases of the University Hospital of Verona"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6535-705X","authenticated-orcid":false,"given":"Anna","family":"Bertaso","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Public Health, Unit of Forensic Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-1723","authenticated-orcid":false,"given":"Rossella","family":"Gottardo","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Public Health, Unit of Forensic Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Murari","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Public Health, Unit of Forensic Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Mazzola","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Public Health, Unit of Forensic Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2198-8316","authenticated-orcid":false,"given":"Nadia Maria","family":"Porpiglia","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Public Health, Unit of Forensic Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4728-6686","authenticated-orcid":false,"given":"Francesco","family":"Taus","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Public Health, Unit of Forensic Medicine University of Verona  Verona Italy"},{"name":"Department of Diagnostic and Public Health, Unit of Epidemiology and Medical Statistics University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Beghini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Verona University Hospital  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Gandini","sequence":"additional","affiliation":[{"name":"Social Services Verona University Hospital  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9568-4585","authenticated-orcid":false,"given":"Federica","family":"Bortolotti","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Public Health, Unit of Forensic Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"National Institute on Drug Abuse Substance use while pregnant and breast feeding. 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