{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:40:55Z","timestamp":1787856055032,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, lysergic acid diethylamide (LSD) analogs have appeared worldwide as designer drugs. In this study, we identified a distributed LSD analog from a paper\u2010sheet product. Gas chromatography\u2013mass spectrometry (GC\u2010MS), liquid chromatography\u2013photodiode array\u2013mass spectrometry (LC\u2010PDA\u2010MS), and liquid chromatography with hybrid quadrupole time\u2010of\u2010flight mass spectrometry (LC\u2010QTOF\u2010MS) were used to analyze the sheet product. The sheet product claimed to contain 1\u2010(1,2\u2010dimethylcyclobutanoyl)\u2010<jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010diethyllysergamide (1D\u2010LSD). However, an unknown compound was detected in the product together with tryptamine and L\u2010tryptophan methyl ester. This compound was isolated from the sheets and identified as 1\u2010(thiophene\u20102\u2010carbonyl)\u2010<jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010diethyl\u20106\u2010methyl\u20109,10\u2010didehydroergoline\u20108\u03b2\u2010carboxamide (1\u2010thiophenoyl LSD; 1\u2010(2\u2010thienoyl)\u2010LSD, 1T\u2010LSD), using <jats:sup>1<\/jats:sup>H, <jats:sup>13<\/jats:sup>C nuclear magnetic resonance (NMR) spectroscopy and various two\u2010dimensional NMR techniques. 1T\u2010LSD was shown to have the thiophene\u20102\u2010carbonyl group at the <jats:italic>N<\/jats:italic><jats:sup>1<\/jats:sup> position instead of the 1,2\u2010dimethylcyclobutane\u2010carbonyl group as claimed. The amount of 1T\u2010LSD (free base) in three individual unit from one sheet was determined to be 87\u2013100\u2009\u03bcg per unit using a proton\u2010specific quantitative NMR (<jats:sup>1<\/jats:sup>H\u2010qNMR) method. Deacylation of 1T\u2010LSD to LSD was also observed to occur in methanol\u2010<jats:italic>d<\/jats:italic><jats:sub>4<\/jats:sub> during NMR analysis. The UV spectrum of 1T\u2010LSD differed from that of other LSD analogs, and the fluorescence sensitivity was much lower. Because of concerns about the future distribution of products containing new LSD analogs, continued monitoring of newly detected compounds in sheet products is encouraged.<\/jats:p>","DOI":"10.1002\/dta.3565","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:33:07Z","timestamp":1692671587000},"page":"482-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of the lysergic acid diethylamide analog, 1\u2010(thiophene\u20102\u2010carbonyl)\u2010<i>N<\/i>,<i>N<\/i>\u2010diethyllysergamide (1T\u2010LSD) from a blotter product"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6432-2867","authenticated-orcid":false,"given":"Rie","family":"Tanaka","sequence":"first","affiliation":[{"name":"Division of Pharmacognosy, Phytochemistry and Narcotics National Institute of Health Sciences  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiko","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy, Phytochemistry and Narcotics National Institute of Health Sciences  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakumi","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy, Phytochemistry and Narcotics National Institute of Health Sciences  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruri","family":"Kikura\u2010Hanajiri","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy, Phytochemistry and Narcotics National Institute of Health Sciences  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19430260326"},{"key":"e_1_2_6_3_1","unstructured":"EMCDDA. 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