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Direct analysis in real\u2010time tandem mass spectrometry was used to rapidly identify 10 benzodiazepines and related metabolites in the blood and urine. The related direct analysis in real\u2010time tandem mass spectrometry parameters were optimized. A liquid\u2013liquid extraction method using ethyl acetate as the extraction solvent was used for sample preparation. The established method was validated and tested on case specimens. The limits of detection of this method ranged from 0.2 to 20\u2009ng\/mL and the limits of quantification from 1 to 50\u2009ng\/mL. The recoveries ranged from 78.8% to 114%, and the matrix effects were in the range of \u221221.2% to 17.9%. The precision and repeatability at high and medium concentrations did not exceed 14.6%, and the limit of quantification did not exceed 18.2%, indicating a desirable linear relationship. The established method was used to determine blood and urine specimens from authentic cases, and promising results were obtained.<\/jats:p>","DOI":"10.1002\/dta.3576","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T02:43:44Z","timestamp":1694832224000},"page":"817-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Rapid detection of 10 benzodiazepines and metabolites in blood and urine using DART\u2010MS\/MS"],"prefix":"10.1002","volume":"16","author":[{"given":"Fubang","family":"Liu","sequence":"first","affiliation":[{"name":"School of Criminal Investigation People's Public Security University of China  Beijing China"},{"name":"Forensic Science Service of Beijing Public Security Bureau, Key Laboratory of Forensic Toxicology Ministry of Public Security  Beijing 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