{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:44:25Z","timestamp":1791855865001,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018712","name":"Universitatea de Medicin\u0103 \u015fi Farmacie Iuliu Ha\u0163ieganu Cluj-Napoca","doi-asserted-by":"publisher","award":["PCD 774\/5\/11.01.2023"],"award-info":[{"award-number":["PCD 774\/5\/11.01.2023"]}],"id":[{"id":"10.13039\/501100018712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A portable and highly sensitive sensor was designed for the specific detection of 3,4\u2010methyl\u2010enedioxy\u2010methamphetamine (MDMA), in a range of field\u2010testing situations. The sensor can detect MDMA in street samples, even when other controlled substances drugs, or adulterants are present. In this work, we report for the first time a sensor using electroactive molecularly imprinted polymer nanoparticles computationally designed to recognize MDMA and then produced using solid phase synthesis. A composite comprising chitosan, reduced graphene oxide, and molecularly imprinted polymer nanoparticles synthesized for MDMA for the first time was immobilized on screen\u2010printed carbon electrodes. The sensors displayed a satisfactory sensitivity (106.8\u00a0nA\u2009\u00d7\u2009\u03bcM\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), limit of detection (1.6\u00a0nM; 0.31\u2009ng\/mL), and recoveries (92\u201399%). The accuracy of the results was confirmed through validation using Ultra\u2010High Performance Liquid Chromatography coupled with tandem Mass Spectrometry (UPLC\u2010MS\/MS). This technology could be used in forensic analysis and make it possible to selectively detect MDMA in street samples.\n                  <\/jats:p>","DOI":"10.1002\/dta.3605","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T19:16:47Z","timestamp":1700767007000},"page":"865-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Design of smart nanoparticles for the electrochemical detection of 3,4\u2010methylenedioxymethamphetamine to allow in field screening by law enforcement officers"],"prefix":"10.1002","volume":"16","author":[{"given":"Florina Maria","family":"Truta","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro Garcia","family":"Cruz","sequence":"additional","affiliation":[{"name":"Chemistry Department University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1488-5917","authenticated-orcid":false,"given":"Ana\u2010Maria","family":"Dragan","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2572-6724","authenticated-orcid":false,"given":"Mihaela","family":"Tertis","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Cowen","sequence":"additional","affiliation":[{"name":"Chemistry Department University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Geogia","family":"Stefan","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy Iuliu Hatieganu University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Topala","sequence":"additional","affiliation":[{"name":"Department of General and Inorganic Chemistry \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amorn","family":"Slosse","sequence":"additional","affiliation":[{"name":"Drugs and Toxicology Department National Institute for Criminalistics and Criminology (NICC)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Piletska","sequence":"additional","affiliation":[{"name":"Chemistry Department University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Van Durme","sequence":"additional","affiliation":[{"name":"Drugs and Toxicology Department National Institute for Criminalistics and Criminology (NICC)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3036-5345","authenticated-orcid":false,"given":"Bela","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy Iuliu Hatieganu University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolien","family":"De Wael","sequence":"additional","affiliation":[{"name":"A\u2010Sense Lab University of Antwerp  Antwerp Belgium"},{"name":"NANOlab Ctr Excellence University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey A.","family":"Piletsky","sequence":"additional","affiliation":[{"name":"Chemistry Department University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4158-3324","authenticated-orcid":false,"given":"Cecilia","family":"Cristea","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WDR 2022_Booklet 2. Accessed October 6 2023.https:\/\/www.unodc.org\/unodc\/en\/data-and-analysis\/wdr-2022_booklet-2.html"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2020.1784914"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00138"},{"key":"e_1_2_6_5_1","unstructured":"Joint assessment of MDMA trafficking trends|Office of Justice Programs. Accessed May 2 2023.https:\/\/www.ojp.gov\/ncjrs\/virtual-library\/abstracts\/joint-assessment-mdma-trafficking-trends"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/JCPH.1918"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10008\u2010020\u201004686\u2010z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TALANTA.2021.122904"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FORC.2021.100383"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PROCBIO.2021.12.021"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FORSCIINT.2009.03.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826076.2020.1811725"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forc.2020.100268"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TRAC.2021.116447"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/JAT\/14.3.149"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FORSCIINT.2005.04.019"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/BMC.670"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCHROMB.2004.03.076"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0379\u20100738(96)02028\u20102"},{"key":"e_1_2_6_20_1","unstructured":"United Nations Office on Drugs and Crime.Recommended methods for the identification and analysis of amphetamine methamphetamine and their ring\u2010substituted analogues in seized materials (revised and updated) manual for use by national drug testing laboratories. Accessed October 6 2023.www.unodc.org"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207003331382"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coelec.2017.05.001"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coelec.2018.06.014"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.08.009"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41378\u2010020\u201000193\u20103"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNMA.201900056"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0AN00419G"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOS.2020.112536"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3RA46838K"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NA00327D"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCHEM.2021.641147\/BIBTEX"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NA00194A"},{"issue":"1","key":"e_1_2_6_33_1","first-page":"S49","article-title":"Limit of blank, limit of detection and limit of quantitation","volume":"29","author":"Armbruster DA","year":"2008","journal-title":"Clin Biochem Rev"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201064066\u20106.00002\u20102"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149\u20106395(05)80045\u20105"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2020.129128"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA00903A"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.RINP.2017.06.027"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5AY02264A"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/46\/1\/311"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vibspec.2020.103115"},{"key":"e_1_2_6_42_1","unstructured":"UrbanMW.Fourier transform infrared and Fourier transform Raman spectroscopy of polymers principles and applications2023;14:10. Accessed April 20 2023.https:\/\/pubs.acs.org\/sharingguidelines"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369\u20107021(07)70245\u20106"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ELECTACTA.2006.03.090"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SNB.2019.03.138"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ELECTACTA.2013.12.107"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105088"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/elan.202060080"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ELECTACTA.2022.141002"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.3605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T18:08:29Z","timestamp":1760378909000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.3605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/dta.3605"],"URL":"https:\/\/doi.org\/10.1002\/dta.3605","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"value":"1942-7603","type":"print"},{"value":"1942-7611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,22]]},"assertion":[{"value":"2023-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}