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In this epidemiology study, adults were surveyed entering nightclubs and dance festivals in New York City, and 328 provided hair samples, which were analyzed using ultra\u2010high\u2010performance liquid chromatography\u2013tandem mass spectrometry to determine the level of detection of cocaine and 3,4\u2010methylenedioxymethamphetamine (MDMA). Reporting use was not an inclusion criterion for analysis. We used two\u2010part multivariable models to delineate associations of hair color, past\u2010year hair dyeing, and frequency of past\u2010month hat wearing (which may increase perspiration) in relation to any vs. no detection of cocaine and MDMA as well as level of detection, controlling for hair length, self\u2010reported past\u2010year cocaine\/ecstasy\/MDMA use, and age, sex, and race\/ethnicity. Those reporting having dyed their hair were at increased odds of having any level of cocaine detected (adjusted odds ratio [aOR]\u2009=\u20093.75, 95% CI confidence interval [CI]: 1.85\u20136.70), and compared to those with brown hair, those with blond(e) hair on average had lower levels of cocaine (ng\/mg) detected (beta\u2009=\u2009\u22127.97, p\u2009=\u20090.025). Those reporting having dyed their hair were at increased odds of having any level of MDMA detected (aOR\u2009=\u00a03.05, 95% CI: 1.44\u20136.48), and compared to those who reported never wearing a hat, those who reported wearing a hat daily or almost daily on average had lower levels of MDMA (ng\/mg) detected (beta\u2009=\u2009\u22126.61, p\u2009=\u20090.025). This study demonstrates the importance of using multivariable models to delineate predictors of drug detection.<\/jats:p>","DOI":"10.1002\/dta.3607","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T13:28:28Z","timestamp":1700659708000},"page":"855-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A multivariable analysis delineating hair color, hair dyeing, and hat wearing as predictors of level of cocaine and MDMA detection in human hair samples"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8565-9415","authenticated-orcid":false,"given":"Joseph J.","family":"Palamar","sequence":"first","affiliation":[{"name":"Department of Population Health NYU Grossman School of Medicine  New York NY USA"},{"name":"Center for Drug Use and HIV\/HCV Research, School of Global Public Health New York University  New York NY 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