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Subjective, cardiovascular, and endocrine responses were compared with two different doses of 3,4\u2010methylenedioxymethamphetamine (MDMA) (75\u2009mg and 125\u2009mg) described in previously published placebo\u2010controlled studies, which used identical outcome measures including Visual Analogue Scales (VAS), the Adjective Mood Rating Scale (AMRS), and the 5 Dimensions of Altered States of Consciousness (5D\u2010ASC) scale. MDAI was well tolerated and produced subjective effects comparable with those of 125\u2009mg MDMA. MDAI increased blood pressure similar to 125\u2009mg MDMA but did not increase heart rate or body temperature. MDAI increased cortisol and prolactin levels and could be detected in serum about 20\u2009min post ingestion and remained detectable at least for 4\u00a0days. In urine, MDAI was detectable over a period of at least 6\u00a0days. Further clinical investigations are warranted to assess whether MDAI could serve as drug with medicinal properties.<\/jats:p>","DOI":"10.1002\/dta.3622","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T09:03:03Z","timestamp":1701939783000},"page":"1002-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute psychotropic, autonomic, and endocrine effects of 5,6\u2010methylenedioxy\u20102\u2010aminoindane (MDAI) compared with 3,4\u2010methylenedioxymethamphetamine (MDMA) in human volunteers: A self\u2010administration study"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3081-4609","authenticated-orcid":false,"given":"Verena","family":"Angerer","sequence":"first","affiliation":[{"name":"Institute of Forensic Medicine Medical Center \u2013 University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Schmid","sequence":"additional","affiliation":[{"name":"Psychopharmacology Research Division of Clinical Pharmacology and Toxicology Department of Biomedicine and Department of Clinical Research University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-2882","authenticated-orcid":false,"given":"Florian","family":"Franz","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine Medical Center \u2013 University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Gnann","sequence":"additional","affiliation":[{"name":"Research associate  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Manuel","family":"Speer","sequence":"additional","affiliation":[{"name":"Research associate  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Gnann","sequence":"additional","affiliation":[{"name":"Research associate  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Helmecke","sequence":"additional","affiliation":[{"name":"Research associate  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Buchwald","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry and Laboratory Medicine Medical Center \u2013 University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-5372","authenticated-orcid":false,"given":"Simon D.","family":"Brandt","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences Liverpool John Moores University  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6143-0560","authenticated-orcid":false,"given":"Torsten","family":"Passie","sequence":"additional","affiliation":[{"name":"Hannover Medical School  Hannover Germany"},{"name":"Dr. Senckenberg Institute for History and Ethics in Medicine Goethe\u2010University Frankfurt\/Main  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-9659","authenticated-orcid":false,"given":"Matthias E.","family":"Liechti","sequence":"additional","affiliation":[{"name":"Psychopharmacology Research Division of Clinical Pharmacology and Toxicology Department of Biomedicine and Department of Clinical Research University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1883-2804","authenticated-orcid":false,"given":"Volker","family":"Auw\u00e4rter","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine Medical Center \u2013 University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1686"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.274662"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2018_160"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2018_127"},{"key":"e_1_2_5_6_1","unstructured":"EMCDDA. 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