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Knowledge of endogenous concentrations of various steroids in different genders of horses (intact male, castrated male and female) and factors that could naturally affect them is beneficial for establishing ways for detection of their use. The current internationally adopted approaches include concentration\u2010based thresholds in urine and plasma, steroid ratios in urine and targeting the administered intact steroid esters in plasma and hair. However, these have their limitations, and therefore, other strategies, such as additional biomarkers and steroid profiling based on longitudinal testing and multivariate analysis, have been investigated and could potentially improve detection of the use of endogenous steroids in horses. This paper aims to provide a comprehensive overview of the steroids (androgens, oestrogens and progestogens) that have been reported to be endogenous to horses in literature, their concentration ranges in different genders and factors potentially affecting them as well as current and possible future approaches to detect their use.<\/jats:p>","DOI":"10.1002\/dta.3624","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T02:08:27Z","timestamp":1702519707000},"page":"1044-1065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Presence and detection of endogenous steroids in the horse\u2014A review"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-9812","authenticated-orcid":false,"given":"Marjaana","family":"Viljanto","sequence":"first","affiliation":[{"name":"LGC  Cambridgeshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobby","family":"Gray","sequence":"additional","affiliation":[{"name":"LGC  Cambridgeshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Scarth","sequence":"additional","affiliation":[{"name":"LGC  Cambridgeshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010\u20100013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003\u20100030"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203450437_chapter_4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303\u20107207(01)00435\u2010X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.165"},{"key":"e_1_2_6_7_1","unstructured":"International Federation of Horseracing Authorities.2022International agreement on breeding racing and wagering and appendixes. 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