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Several studies suggest that music festival attendees are more likely to abuse illicit substances and have a high\u2010risk profile. Consequently, it is crucial to develop robust field drug analysis methods that facilitate harm reduction and drug monitoring. The work presented in this report aimed at developing and validating qualitative analytical methods for 3,4\u2010methylenedioxymethamphetamine, 4\u2010bromo\u20102,5\u2010dimethoxyphenethylamine (2C\u2010B), ketamine and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010ethylpentylone on two portable gas chromatography\u2013mass spectrometry (GC\u2013MS) systems: Griffin G510 (Teledyne FLIR, West Lafayette, IN) and Torion T\u20109 (PerkinElmer, Shelton, CT). The diagnostic ability of the mobile GC\u2013MS units was assessed on 200 samples in total, seized at two large summer music festivals in the United Kingdom. The method validation process included selectivity\/specificity, limit of identification, carry\u2010over, ruggedness\/robustness, and inter\u2010 and intra\u2010day precision (repeatability and reproducibility). The Griffin G510 demonstrated a limit of identification from 1\u00a0mg\/mL for 2C\u2010B to 0.063\u2009mg\/mL for ketamine and good ruggedness and precision results. The precision for 2C\u2010B using the Torion T\u20109 was poorer than for the Griffin G510, but equivalent for the other compounds tested. Correct identifications (versus benchtop GC\u2013MS) for the two festivals were 85%\u201386% and 74%\u201383% for the Griffin G510 and the Torion T\u20109, respectively. The two portable instruments were able to adequately cover current on\u2010site drug\u2010testing analytical gaps and proved to be a powerful addition to the on\u2010site drug analysis techniques.\n                  <\/jats:p>","DOI":"10.1002\/dta.3629","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:41:41Z","timestamp":1706056901000},"page":"1241-1253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Analysis of drugs seized from amnesty bins at two major United Kingdom summer music festivals using two portable gas chromatography\u2010mass spectrometry (GC\u2013MS) instruments"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9892-4812","authenticated-orcid":false,"given":"Anca","family":"Frinculescu","sequence":"first","affiliation":[{"name":"Department of Analytical, Environmental and Forensic Sciences King's College London  London UK"},{"name":"TICTAC Communications Ltd. 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