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New psychoactive substances including novel benzodiazepines in the illicit drug supply have been linked to high rates of overdose deaths while complicating drug checking as an overdose prevention strategy. Paper\u2010spray mass spectrometry (PS\u2010MS) has emerged as a novel strategy to rapidly detect trace components in street drug samples. While targeted, low\u2010resolution PS\u2010MS methods have proven effective, newly emerging substances are often missed. To address this, a method was applied to low\u2010resolution full\u2010scan PS\u2010MS data to aid in the early detection and identification of novel benzodiazepines in the unregulated drug supply. Using the developed method, true positives rates of 0.89 and 0.75 were achieved for bromazolam and etizolam in street samples obtained in a community drug checking service. 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