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A skeletonized body was discovered on a country road. A tuft of brown hair, detached from the scalp, irregular in length, non\u2010oriented, in contact with soil and vegetation, was removed. An anthropological examination was carried out and genetic samples were taken from the right femoral shaft. After about 10 washes with warm water and dichloromethane, the tuft of hair was analyzed without segmentation. General unknown screening was performed by liquid chromatography system coupled to a high\u2010resolution mass spectrometry (LC\u2010HRMS) after incubation in pH\u00a09.5 borate buffer and liquid\u2013liquid extraction. Specific Multiple Reaction Monitoring (MRM) methods for date rape drugs were carried out by liquid chromatography system coupled to a tandem mass spectrometry (LC\u2010MS\/MS). The anthropological examination allowed to determine that the victim was a female individual, over 60\u2009years old, the death dating from 3\u00a0months to 1\u00a0year. Comparison of the DNA results with the Missing Persons Index led to the identification, a 60\u2010year\u2010old woman who disappeared 5\u2009months earlier. Hair analysis showed the presence of oxazepam (361\u2009pg\/mg), nordiazepam (54\u2009pg\/mg), and alimemazine (5\u00a0pg\/mg). The interpretation of these concentrations is extremely difficult due to the risk of degradation of the hair cuticle during prolonged stay in the soil, as well as of contamination by putrefactive fluids. The authors discuss the value of using multiple biological and non\u2010biological matrices in this context to improve the interpretation of the results.<\/jats:p>","DOI":"10.1002\/dta.3649","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T03:34:38Z","timestamp":1705721678000},"page":"1219-1224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hair analysis in postmortem investigations: Case of a skeletonized body"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-6750","authenticated-orcid":false,"given":"Anne\u2010Laure","family":"Pelissier\u2010Alicot","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine L\u00e9gale Aix Marseille Univ, APHM, H\u00f4pital La Timone  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1117-0887","authenticated-orcid":false,"given":"Alice","family":"Ameline","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine L\u00e9gale  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4174-5362","authenticated-orcid":false,"given":"Pascal","family":"Kintz","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine L\u00e9gale  Strasbourg France"},{"name":"X\u2010Pertise Consulting, Mittelhausbergen  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Adalian","sequence":"additional","affiliation":[{"name":"Aix Marseille UNIV, CNRS, EFS, ADES  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Leonetti","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine L\u00e9gale Aix Marseille Univ, APHM, H\u00f4pital La Timone  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"key":"e_1_2_1_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170929155628"},{"key":"e_1_2_1_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.02.012"},{"key":"e_1_2_1_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414\u2010020\u201002267\u20103"},{"key":"e_1_2_1_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2022.102032"},{"key":"e_1_2_1_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkab040"},{"key":"e_1_2_1_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.01.041"},{"key":"e_1_2_1_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxac.2018.06.002"},{"key":"e_1_2_1_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2007.08.009"},{"key":"e_1_2_1_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2012.10.012"},{"key":"e_1_2_1_6_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11100686"},{"key":"e_1_2_1_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/30.6.400"},{"key":"e_1_2_1_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.12.036"},{"key":"e_1_2_1_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2016.08.010"},{"key":"e_1_2_1_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2017.12.001"},{"key":"e_1_2_1_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2006.03.027"},{"key":"e_1_2_1_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20104347(95)00444\u20100"},{"key":"e_1_2_1_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378\u20104347(97)00337\u2010x"},{"key":"e_1_2_1_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010416748\u20103.00008\u20106"},{"key":"e_1_2_1_6_20_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.14.165"},{"key":"e_1_2_1_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkv067"},{"key":"e_1_2_1_6_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170704123126"},{"key":"e_1_2_1_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2021.110935"},{"key":"e_1_2_1_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2018.06.024"},{"key":"e_1_2_1_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2020.110225"},{"key":"e_1_2_1_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2017.08.006"},{"key":"e_1_2_1_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.120533"},{"key":"e_1_2_1_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414\u2010010\u20100525\u20106"},{"key":"e_1_2_1_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkaa083"},{"key":"e_1_2_1_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxac.2019.01.003"},{"key":"e_1_2_1_6_31_1","unstructured":"StimpflT MullerK GergovM et al.Recommendations on sample collection. 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