{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:51Z","timestamp":1786977711505,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Point\u2010of\u2010collection testing (POCT) devices are widely used in roadside and workplace drug testing to identify recent cannabis use by measuring the presence of \u0394\n                    <jats:sup>9<\/jats:sup>\n                    \u2010tetrahydrocannabinol (THC) in oral fluid (OF). However, the performance of POCT devices with oral medicinal cannabis products remains poorly described. In a randomised, double\u2010blinded, crossover trial, adults with insomnia disorder (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200920) received a single (2\u00a0mL) oral dose of oil containing 10\u00a0mg THC\u2009+\u2009200\u2009mg cannabidiol, or placebo, prior to sleep. Participants were tested with the Securetec DrugWipe\u00ae 5S (10\u00a0ng\/mL THC cut\u2010off) and Dr\u00e4ger DrugTest\u00ae 5000 (25\u2009ng\/mL THC cut\u2010off) POCT devices at baseline (pre\u2010treatment) and then at 0.5, 10, and 18\u2009h post\u2010treatment. An OF sample, taken at each time point, was also analysed using liquid chromatography\u2013tandem mass spectrometry. Large individual variability in OF THC concentrations was observed 0.5\u00a0h post\u2010treatment (range: 0\u2013425\u2009ng\/mL; mean (\n                    <jats:italic>SD<\/jats:italic>\n                    ) 48.7\u00a0(107.5)\u00a0ng\/mL). Both the Securetec DrugWipe\u00ae 5S and DrugTest\u00ae 5000 demonstrated poor sensitivity to THC at 0.5\u00a0h post\u2010treatment (25% and 50%, respectively). At 10 and 18\u2009h post\u2010treatment, all participant OF THC concentrations were below screening cut\u2010offs, and all test results were negative. These findings highlight the relatively poor sensitivity of both devices in detecting recent use of an oral medicinal cannabis product. They also suggest a low probability of obtaining a positive THC result the morning after (\u2018one\u2010off\u2019) use. Further research is required to establish the probability of obtaining a positive THC result with regular medicinal cannabis use.\n                  <\/jats:p>","DOI":"10.1002\/dta.3658","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T23:35:55Z","timestamp":1709076955000},"page":"1487-1495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Detection of \u0394\n                    <sup>9<\/sup>\n                    \u2010tetrahydrocannabinol (THC) in oral fluid using two point\u2010of\u2010collection testing devices following oral administration of a THC and cannabidiol\u00a0containing oil"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5993-2246","authenticated-orcid":false,"given":"Anastasia","family":"Suraev","sequence":"first","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics University of Sydney  Sydney New South Wales Australia"},{"name":"Centre for Sleep and Chronobiology Woolcock Institute of Medical Research  Sydney New South Wales Australia"},{"name":"School of Psychology, Faculty of Science University of Sydney  Sydney New South Wales Australia"},{"name":"Brain and Mind Centre University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-5220","authenticated-orcid":false,"given":"Danielle","family":"McCartney","sequence":"additional","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics University of Sydney  Sydney New South Wales Australia"},{"name":"School of Psychology, Faculty of Science University of Sydney  Sydney New South Wales Australia"},{"name":"Brain and Mind Centre University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kevin","sequence":"additional","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics University of Sydney  Sydney New South Wales Australia"},{"name":"St Vincent's Hospital Sydney  Sydney New South Wales Australia"},{"name":"School of Clinical Medicine, Faculty of Medicine and Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Gordon","sequence":"additional","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald R.","family":"Grunstein","sequence":"additional","affiliation":[{"name":"Centre for Sleep and Chronobiology Woolcock Institute of Medical Research  Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"},{"name":"Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla M.","family":"Hoyos","sequence":"additional","affiliation":[{"name":"Centre for Sleep and Chronobiology Woolcock Institute of Medical Research  Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Human Health Sciences Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain S.","family":"McGregor","sequence":"additional","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics University of Sydney  Sydney New South Wales Australia"},{"name":"School of Psychology, Faculty of Science University of Sydney  Sydney New South Wales Australia"},{"name":"Brain and Mind Centre University of Sydney  Sydney New South Wales 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