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At the roadside, 8945 oral fluid THC screening tests were performed with four devices: AquilaScan\u00ae, Dr\u00e4ger DrugTest\u00ae, WipeAlyser Reader\u00ae, and Druglizer\u00ae. A total of 530 samples screened positive for THC (5.9%) and were analyzed by liquid chromatography\u2013tandem mass spectrometry at multiple cutoff concentrations (2\u00a0ng\/mL, 10\u00a0ng\/mL, and manufacturers' recommended device cutoffs) to investigate device performance. Results varied substantially, with sensitivities of 0%\u201396.8%, specificities of 89.8%\u201398.5%, and efficiencies of 84.3%\u201397.8%. The Dr\u00e4ger DrugTest\u00ae outperformed the other devices with a 96.8% sensitivity, 97.1% specificity, and 97.0% efficiency at a 5\u2010ng\/mL LC\u2013MS\/MS confirmation cutoff. The WipeAlyser Reader\u00ae had good performance with a 91.4% sensitivity, 97.2% specificity, and 96.4% efficiency. AquilaScan\u00ae and Druglizer\u00ae had unacceptable performance for cannabinoid detection, highlighted by sensitivity &lt;13%. The choice of roadside oral fluid testing device must offer good analytical performance for cannabinoids because of its high prevalence of use and impact on road safety.<\/jats:p>","DOI":"10.1002\/dta.3669","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T05:31:49Z","timestamp":1709616709000},"page":"1528-1536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reliability of roadside oral fluid testing devices for \u2206<sup>9<\/sup>\u2010tetrahydrocannabinol (\u2206<sup>9<\/sup>\u2010THC) detection"],"prefix":"10.1002","volume":"16","author":[{"given":"Juliana Nichterwitz","family":"Scherer","sequence":"first","affiliation":[{"name":"Center for Drug and Alcohol Research Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Sa\u00fade Coletiva Universidade do Vale do Rio dos Sinos (UNISINOS)  S\u00e3o 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