{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:02:25Z","timestamp":1787500945001,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Olanzapine (OLZ), a second\u2010generation antipsychotic drug, is effective in the treatment of acute psychosis, schizophrenia, agitation, bipolar mania, and other psychiatric problems. Antipsychotics are prescribed drugs, which lead the drug abuser to illegal methods of access. This behavior also demonstrates the association of OLZ with criminal involvement, commonly observed at forensic crime scenes. The acute toxicity and even death resulting from OLZ exposure have been highlighted in numerous studies. Therefore, developing analytical techniques to detect OLZ is essential for forensic toxicology. This study aimed to develop a specific and reliable LC\u2013MS\/MS method for OLZ detection and quantification in hair samples. The method was validated in terms of selectivity, linearity, limit of detection (LOD), limit of quantification (LOQ), trueness, precision, and uncertainty. The range of linearity was between 0.1\u2013100\u2009ng\/mg, with LOD and LOQ values established at 0.036\u2009ng\/mg and 0.1\u00a0ng\/mg, respectively. All validation results are within acceptable parameters. The validated method has been applied to authentic hair samples. The variation of OLZ concentrations in 12 hair segments (2 from Case 1 and 10 from Case 2) from two drug\u2010positive patients, ranging from 0.131 to 0.460\u2009ng\/mg, is presented in this study. Although several studies have been conducted to determine OLZ in hair samples using segmental analysis via hair solubilization, this study is the first to determine OLZ in hair samples after \u201cdigestion\u201d with comparative parameters prior to chromatographic analysis.<\/jats:p>","DOI":"10.1002\/dta.3744","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T01:53:59Z","timestamp":1717638839000},"page":"412-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["LC\u2013MS\/MS quantification of olanzapine in hair after alkaline digestion"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-7520","authenticated-orcid":false,"given":"Zeynep","family":"Turkmen","sequence":"first","affiliation":[{"name":"Department of Science, Institute of Forensic Sciences and Legal Medicine Istanbul University\u2010Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7082-6156","authenticated-orcid":false,"given":"Zeynep","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Science, Institute of Forensic Sciences and Legal Medicine Istanbul University\u2010Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-7348","authenticated-orcid":false,"given":"Merve","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Science, Institute of Forensic Sciences and Legal Medicine Istanbul University\u2010Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3683-945X","authenticated-orcid":false,"given":"Murat","family":"Yayla","sequence":"additional","affiliation":[{"name":"Department of Science, Institute of Forensic Sciences and Legal Medicine Istanbul University\u2010Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5146-2254","authenticated-orcid":false,"given":"Isil","family":"Bavunoglu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cerrahpa\u015fa Medical Faculty Istanbul University\u2010Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"issue":"10","key":"e_1_2_8_2_1","first-page":"55","article-title":"The relationship of pharmacology to side effects","volume":"58","author":"Casey DE","year":"1997","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245617"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.9.1248"},{"key":"e_1_2_8_5_1","volume-title":"Second\u2010generation antipsychotic medications: pharmacology, administration, and side effects","author":"Jibson MD","year":"2017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bky036"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2020.113510"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-815846-3.00037-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0379\u20100738(02)00051\u20108"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/104454604773840526"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S117321"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.3.360"},{"key":"e_1_2_8_13_1","unstructured":"Zyprexa (olanzapine) [package insert]. 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