{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:17:38Z","timestamp":1789237058096,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Homicide, suicide, or accident \u2013 elemental intoxication may be a cause in each of these types of deaths. Inductively coupled plasma mass spectrometry (ICP\u2010MS) has emerged as the gold standard analytical method for toxic metal analysis in both clinical and forensic settings. An ICP\u2010MS method was developed using a modified acidic workup for the quantitative determination of arsenic, lead, and thallium. Method validation focused on the assessment of linearity, between\u2010 and within\u2010day precisions, limits of detection (LoD) and lower limits of quantification (LLoQ), and carryover. The method was applied to analysis of postmortem peripheral blood samples from 279 forensic cases for which orders for chemical\u2013toxicological examination had been received from the public prosecutor's office. Using six\u2010point and one\u2010point calibrations (latter for rapid screening purposes), precisions and accuracies ranged from \u22124.8 to 5.8% and \u22126.4 to 7.5%. Analytical sensitivities for As, Pb, and Tl were 0.08, 0.18, and 0.01\u2009\u03bcg\/l (LoD) and 0.23, 0.66, and 0.03\u2009\u03bcg\/l (LLoQ), respectively. Observed postmortem peripheral blood concentrations were As, 1.31\u2009\u00b1\u20093.42\u2009\u03bcg\/L; Pb, 17.4\u2009\u00b1\u200913.1\u2009\u03bcg\/L; and Tl, 0.11\u2009\u00b1\u20090.07\u2009\u03bcg\/L (mean \u00b1 standard deviation [SD]). Elemental concentrations, determined in additional quality control samples, were in good agreement to those obtained with an external ICP\u2010MS method based on alkaline sample processing. The current method is practicable and compatible with an ICP\u2010MS system used for trace element analysis in an accredited medical laboratory. It allows for implementation of low\u2010threshold investigations when metal intoxications are suspected in forensic routine.<\/jats:p>","DOI":"10.1002\/dta.3749","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T21:04:52Z","timestamp":1718658292000},"page":"470-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The undetected murder? Evaluation and validation of a practicable and rapid inductively coupled plasma\u2010mass spectrometry method for the detection of arsenic, lead, and thallium intoxications in postmortem blood"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-446X","authenticated-orcid":false,"given":"Martin H. 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