{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:44:37Z","timestamp":1789177477136,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    External contamination is a well\u2010recognized limitation of hair analysis for drugs of abuse like methylamphetamine (MA), and there are no guidelines regarding the analysis of specific metabolites of MA to assist interpretation. We developed an analytical method to detect MA, amphetamine (AMP), and\n                    <jats:italic>para<\/jats:italic>\n                    \u2010hydroxy\u2010methylamphetamine (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010OH\u2010MA) in hair and present their concentrations among a cohort of deceased persons positive for MA in blood (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200963). Hair samples (\u2264 3\u00a0cm) were washed with dichloromethane and water prior to extraction using a methanolic micro\u2010pulverization. The reconstituted hair extracts were separated on a UCT Selectra\u00ae Aqueous C18 HPLC Column (100\u2009\u00d7\u20092.1\u00a0mm, 3\u00a0\u03bcm) by gradient elution and detected using a Sciex Triple Quad 6500+ system. Validation was satisfactory, and the lower limits of quantitation\u00a0were 0.01\u2009ng\/mg for MA and AMP and 0.001\u2009ng\/mg for\n                    <jats:italic>p<\/jats:italic>\n                    \u2010OH\u2010MA. The median hair concentrations of MA, AMP, and\n                    <jats:italic>p<\/jats:italic>\n                    \u2010OH\u2010MA were 13\u2009ng\/mg (range\u2009=\u20090.015\u201349;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200951), 1.1\u00a0ng\/mg (range\u2009=\u20090.018\u201344;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200960), and 0.020\u2009ng\/mg (range\u2009=\u20090.0012\u20130.38,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200962), respectively. These concentrations in hair were strongly positively correlated (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009.7202 to .8641,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001), suggesting similar modes of incorporation. Moreover, the wash\/hair ratios were indicative of external contamination, especially among the soiled group of hair samples. Therefore, further studies are necessary to determine concentrations of\n                    <jats:italic>p<\/jats:italic>\n                    \u2010OH\u2010MA in living MA users and confirm if this metabolite constitutes a potential marker of MA consumption.\n                  <\/jats:p>","DOI":"10.1002\/dta.3765","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T05:57:40Z","timestamp":1719813460000},"page":"544-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The analysis of methylamphetamine and\n                    <i>para<\/i>\n                    \u2010hydroxy\u2010methylamphetamine in post\u2010mortem hair samples using liquid chromatography\u2013tandem mass spectrometry"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8943-8994","authenticated-orcid":false,"given":"Dylan","family":"Mantinieks","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine, School of Public Health and Preventive Medicine Monash University  Southbank Victoria Australia"},{"name":"Victorian Institute of Forensic Medicine  Southbank Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8953-0312","authenticated-orcid":false,"given":"Olaf H.","family":"Drummer","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, School of Public Health and Preventive Medicine Monash University  Southbank Victoria Australia"},{"name":"Victorian Institute of Forensic Medicine  Southbank Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8870-6272","authenticated-orcid":false,"given":"Jennifer","family":"Schumann","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, School of Public Health and Preventive Medicine Monash University  Southbank Victoria Australia"},{"name":"Victorian Institute of Forensic Medicine  Southbank Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7958-8235","authenticated-orcid":false,"given":"Dimitri","family":"Gerostamoulos","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, School of Public Health and Preventive Medicine Monash University  Southbank Victoria Australia"},{"name":"Victorian Institute of Forensic Medicine  Southbank Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)32230\u20105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18356\/9789210028233"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dar.12426"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024\u2010023\u201000724\u20100"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.02.019"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.02.027"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3526"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024\u2010018\u20109994\u20106"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2681"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.01.041"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3649"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS11178J"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2006.01.010"},{"key":"e_1_2_9_15_1","volume-title":"Australian Medicines Handbook","author":"Australian Medicines Handbook Pty Ltd","year":"2024"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010016\u20109354\u2010x"},{"issue":"9","key":"e_1_2_9_17_1","first-page":"1059","article-title":"Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6","volume":"25","author":"Lin LY","year":"1997","journal-title":"Drug Metab. 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