{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:01:53Z","timestamp":1788843713457,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Monitoring of drug use in athletes is of interest both for health and competition\u2010related issues. Considering the advantages of Dried Blood Sampling (low invasiveness, easy sampling, long term storage), we have validated a quantitative LC\u2013MS\/HRMS method for the screening of 16 nonsteroidal anti\u2010inflammatory drugs. For all drugs, accuracy and imprecision were within 15% for the 3 levels of quality control and lower than 20% for the lower limit of quantification. Application was performed from samples obtained for Ultra\u2010Trail du Mont\u2010Blanc\u00ae 2021 and 2022. A focus on ibuprofen and its metabolites (hydroxyibuprofen, carboxyibuprofen, ibuprofen glucuronide and hydroxyibuprofen glucuronide) was made because the results showed that it was the most detected nonsteroidal anti\u2010inflammatory drug. Further, an interpretation of the ibuprofen concentrations was proposed either from experimental data obtained after an intake of ibuprofen by 10 control subjects, or from a pharmacokinetic modelling and simulations. Depending on the analytical performances of the method, we proposed possible detection windows for ibuprofen in runners. The pharmacokinetic model made it possible to consider two scenarios with and without modification of the total clearance of ibuprofen linked to a modification of the pharmacokinetics of the drugs due to the practice of a long and intense physical activity.<\/jats:p>","DOI":"10.1002\/dta.3781","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T01:30:01Z","timestamp":1723771801000},"page":"825-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quantitative analysis of nonsteroidal anti\u2010inflammatory drugs in dried blood spot from mountain ultra\u2010trail runners. Contribution of pharmacokinetic models for the interpretation of the results"],"prefix":"10.1002","volume":"17","author":[{"given":"Mohammad Shafiq","family":"Mashal","sequence":"first","affiliation":[{"name":"Biochemistry and Pharmacology\u2010Toxicology Laboratory, Lyon Sud Hospital University Hospital of Lyon  Pierre\u2010B\u00e9nite France"},{"name":"Toxicology Department Pharmacy Faculty of Kabul University  Kabul Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6180-5708","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Guitton","sequence":"additional","affiliation":[{"name":"Biochemistry and Pharmacology\u2010Toxicology Laboratory, Lyon Sud Hospital University Hospital of Lyon  Pierre\u2010B\u00e9nite France"},{"name":"Pharmacology\u2010Physiology\u2010Toxicology Department, ISPB Pharmacy Faculty of Lyon University of Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sallet","sequence":"additional","affiliation":[{"name":"Association Athlete For Transparency  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bourguignon","sequence":"additional","affiliation":[{"name":"Pharmacology\u2010Physiology\u2010Toxicology Department, ISPB Pharmacy Faculty of Lyon University of Lyon  Lyon France"},{"name":"Pharmacy Department University Hospital of Lyon, GH Nord  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4494-8034","authenticated-orcid":false,"given":"Christelle","family":"Machon","sequence":"additional","affiliation":[{"name":"Biochemistry and Pharmacology\u2010Toxicology Laboratory, Lyon Sud Hospital University Hospital of Lyon  Pierre\u2010B\u00e9nite France"},{"name":"Analytical chemistry laboratory, ISPB Pharmacy Faculty of Lyon University of Lyon  France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15438627.2017.1282356"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003374"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAJSM.495"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3374"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/sports5010011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3216"},{"key":"e_1_2_8_8_1","unstructured":"ITRA Press statement. 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