{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:28:03Z","timestamp":1776436083842,"version":"3.51.2"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T00:00:00Z","timestamp":1726963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>A patient was prescribed a new treatment, 40 mg furosemide. Her pharmacist mistakenly dispensed 40\u2009mg gliclazide instead. After 3\u2009weeks of treatment, the patient was found in a coma, was hospitalised and died after a week. Hair sample was collected during post\u2010mortem<\/jats:italic> examination and tested for gliclazide on three 2\u2009cm sections, starting at the root end. Hair strands were decontaminated, segmented and incubated in the presence of diazepam\u2010d5<\/jats:sub>, and a solid\u2013liquid extraction has been performed. Finally, toxicological analyses were performed by UFLC Shimadzu Prominence \u2010 MS\/MS Sciex 6500 QTRAP. Gliclazide was found on the proximal (238\u2009pg\/mg), median (77\u2009pg\/mg) and distal (69\u2009pg\/mg) segments. The concentration in the proximal segment was largely higher than in the other two, which demonstrates repeated intake of gliclazide by the patient during at least the last 2\u2009months before death. The lower concentrations in the medial and distal segments, as well as a part of the concentration in the proximal segment, may be linked to external hair contamination. These could be due to either radial sweat diffusion, possibly occurring in the last week hospitalisation of the patient, or to biological fluids contamination during post\u2010mortem<\/jats:italic> examination. This case illustrates the opportunity to confirm slow and fatal chronic poisoning by gliclazide using hair analysis and shows the benefit of hair testing for the investigation of medical or dispensing errors.<\/jats:p>","DOI":"10.1002\/dta.3809","type":"journal-article","created":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T19:05:57Z","timestamp":1727031957000},"page":"1049-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Suitability of Hair Testing in Medical Dispensing Errors: A Fatal Case of Gliclazide Poisoning"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0975-9785","authenticated-orcid":false,"given":"S.","family":"Riess","sequence":"first","affiliation":[{"name":"Laboratoire Toxlab Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Klinger","sequence":"additional","affiliation":[{"name":"Laboratoire ChemTox Illkirch France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Roussel","sequence":"additional","affiliation":[{"name":"Laboratoire ChemTox Illkirch France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cheze","sequence":"additional","affiliation":[{"name":"Laboratoire Toxlab Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laboratoire Toxlab Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Cirimele","sequence":"additional","affiliation":[{"name":"Laboratoire Toxlab Paris France"},{"name":"Laboratoire ChemTox Illkirch France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,22]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization (WHO) \u201cPatient safety \u201d published September 11 2023 accessed February 1 2024 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/patient\u2010safety."},{"key":"e_1_2_6_3_1","unstructured":"National Health Service (NHS) \u201cDid You Know High Level Medicatio Errors \u201d published online March 2022 https:\/\/resolution.nhs.uk\/wp\u2010content\/uploads\/2022\/03\/Did\u2010You\u2010Know\u2010High\u2010Level\u2010Medication\u2010Errors.pdf."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2023.10.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxac.2020.02.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2012.08.014"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.3809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T18:46:30Z","timestamp":1760381190000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.3809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,22]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/dta.3809"],"URL":"https:\/\/doi.org\/10.1002\/dta.3809","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"value":"1942-7603","type":"print"},{"value":"1942-7611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,22]]},"assertion":[{"value":"2024-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}