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This study reports on waxy\u2010 or putty\u2010like materials as a novel drug preparation for SCRAs and other drugs seized from UK prisons. In 2023, 22 of these new preparations were seized from Scottish prisons, with eight found in sealed vape pods. The materials were positive for SCRAs, phytocannabinoids, novel benzodiazepines, and\/or gabapentinoids. Additionally, 11 preparations were seized from an English prison, all containing the SCRAs MDMB\u20104en\u2010PINACA and MDMB\u2010INACA. MDMB\u2010INACA was pharmacologically characterized using in\u00a0vitro CB<jats:sub>1<\/jats:sub> and CB<jats:sub>2<\/jats:sub> bioassays, revealing moderate efficacy but low potency at CB<jats:sub>1<\/jats:sub>. Furthermore, the in\u00a0vitro CB<jats:sub>1<\/jats:sub> bioassay was also used to evaluate the CB<jats:sub>1<\/jats:sub> activating potential of extracts from eight seized samples. Six of these showed high CB<jats:sub>1<\/jats:sub> activity, whereas the samples lacking SCRAs or containing only MDMB\u2010INACA showed no or only weak CB<jats:sub>1<\/jats:sub> activity, respectively. Lastly, applying the bioassay as an activity\u2010based \u201cuntargeted\u201d screening method effectively identified the presence of SCRAs in one waxy preparation, which was initially not detected by gas chromatography\u2013mass spectrometry (GC\u2010MS). This underscores the effectiveness of the bioassay for evaluating these new waxy\u2010 or putty\u2010like materials for the presence of SCRAs.<\/jats:p>","DOI":"10.1002\/dta.3817","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T02:39:51Z","timestamp":1729046391000},"page":"1118-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Waxy\u2010 or Putty\u2010Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In\u00a0Vitro Cannabinoid Receptor Activity"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5282-4576","authenticated-orcid":false,"given":"Axelle","family":"Timmerman","sequence":"first","affiliation":[{"name":"Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences Ghent University  Ghent 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