{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T11:36:31Z","timestamp":1787916991757,"version":"build-2784847793"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A new nicotine delivery system in the form of tobacco\u2010free nicotine pouches was introduced in Europe in 2019. These nicotine bags did not fall under the Tobacco Products Directive (TPD) II, which brought forward regulatory requirements for both cigarettes, related products, and e\u2010liquids. As these pouches did not fall under the scope of the TPD, it was up to the member states to decide which action to be taken if any. Some EU member states banned these nicotine pouches, while others put restrictions on the amount of nicotine, warning messages, and presentation and packaging of the product, and some member states did not take any action. Likely as a result of the ban or restrictions, soon after also, tobacco and nicotine\u2010free pouches became available in the European Union (EU). Early 2024, \u201cNoNIC\u201d pouches, claiming to be tobacco\u2010 and nicotine\u2010free, became available on the European market. These pouches are promoted online and clearly target a younger population with a youth\u2010appealing package design and enticing flavors. Upon analysis of different samples utilizing gas chromatography coupled to MS (GC\u2013MS), liquid chromatography coupled to high\u2010resolution tandem mass spectrometry (HRAM LC\u2013MS2), and nuclear magnetic resonance spectroscopy (NMR), it was demonstrated that these pouches were indeed devoid of nicotine but contained the synthetic nicotine homolog 6\u2010methyl nicotine (6\u2010MN) and this up to 20\u2009mg per pouch. Nonetheless, a part of a likely unaware\/misled young adult subpopulation has easy access to these products, containing a novel molecule for which limited to no clinical effects are known.<\/jats:p>","DOI":"10.1002\/dta.3841","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T03:10:51Z","timestamp":1734577851000},"page":"1368-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Emergence of a Novel Synthetic Nicotine Analog 6\u2010Methyl Nicotine (6\u2010MN) in Proclaimed Tobacco\u2010 and Nicotine\u2010Free Pouches Available in Europe"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-3706","authenticated-orcid":false,"given":"Celine","family":"Vanhee","sequence":"first","affiliation":[{"name":"Service Medicines and Health Products, Scientific Direction of Chemical and Physical Health Risks Sciensano  Brussels 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Medicines and Health Products, Scientific Direction of Chemical and Physical Health Risks Sciensano  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960\u20109822(00)00336\u20105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.48.113006.094742"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5671\u201010.2011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421\u2010018\u20100060\u2010z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010021\u201005884\u2010x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666171103152136"},{"key":"e_1_2_9_8_1","volume-title":"Neuropathology of Drug Addictions and Substance Misuse","author":"Beer 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