{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:01:02Z","timestamp":1760403662453,"version":"build-2065373602"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Methylsulfonylmethane (MSM), also known as dimethyl sulfone, is a naturally occurring sulphur\u2010containing compound that can be found in plants, animals and humans. MSM can also be a metabolite of dimethyl sulfoxide (DMSO). Due to their anti\u2010inflammatory and analgesic effects, both MSM and DMSO are prohibited substances in horseracing. As both substances are naturally occurring, their misuse in horses is controlled by International Residue Limits (IRL) of 1200 and 15\u2009\u03bcg\/mL, respectively, in horse urine as established by the International Federation of Horseracing Authorities. The elimination of DMSO in horses has been reported; however, there has been no report on the elimination of MSM in horses. This paper describes a pilot study of an administration study of MSM in two geldings following one scoop (~15\u2009g) of Pure MSM twice daily for six consecutive days. MSM in post\u2010administration urine and blood samples was quantified by gas chromatography\u2013mass spectrometry after sample dilution, with additional protein precipitation for the blood samples. The elimination profiles of MSM in urine and blood are described. The maximum detection time in urine at the IRL of 1200\u2009\u03bcg\/mL was around 4.5\u2009days after the last dose. Plasma MSM in both horses was around 120\u2009\u03bcg\/mL at 4.4\u2009days after the last dose, which was the last blood sample collected. As such, 120\u2009\u03bcg\/mL may indicate a possible IRL for controlling MSM in horse blood. The analysis of DMSO in post\u2010MSM\u2010administration samples showed that DMSO is not a significant metabolite of MSM in horses.<\/jats:p>","DOI":"10.1002\/dta.3844","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T03:39:26Z","timestamp":1734752366000},"page":"1380-1383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Doping Control Analysis of Methylsulfonylmethane in Horses"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8245-6770","authenticated-orcid":false,"given":"Jenny\u00a0K.\u00a0Y.","family":"Wong","sequence":"first","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin N.T. Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timmy\u00a0L.\u00a0S.","family":"Choi","sequence":"additional","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin N.T. Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia\u00a0O.\u00a0L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin N.T. Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Curl","sequence":"additional","affiliation":[{"name":"Department of Veterinary Regulation, Welfare and Biosecurity Policy The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin N.T. Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3779-2649","authenticated-orcid":false,"given":"Terence\u00a0S.\u00a0M.","family":"Wan","sequence":"additional","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin N.T. Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmie\u00a0N.\u00a0M.","family":"Ho","sequence":"additional","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin N.T. Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00107a049"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030290"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep045"},{"issue":"4","key":"e_1_2_8_5_1","first-page":"438","article-title":"Methansulfonylmethane (MSM). Monograph","volume":"8","year":"2003","journal-title":"Alternative Medicine Review: A Journal of Clinical Therapeutic"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.03.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0147-50-45"},{"key":"e_1_2_8_8_1","unstructured":"International Federation of Horseracing Authorities (IFHA) InternResidue Limits\u2014Urine and Plasma accessed on June 4 2024 https:\/\/www.ifhaonline.org\/default.asp?section=IABRW&area=18."},{"key":"e_1_2_8_9_1","first-page":"229","volume-title":"Proceedings of the 44th Meeting of the Association of Official Racing Chemists","author":"Law W. C.","year":"1991"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12476"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.3844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T18:43:32Z","timestamp":1760381012000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.3844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,21]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/dta.3844"],"URL":"https:\/\/doi.org\/10.1002\/dta.3844","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"type":"print","value":"1942-7603"},{"type":"electronic","value":"1942-7611"}],"subject":[],"published":{"date-parts":[[2024,12,21]]},"assertion":[{"value":"2024-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}