{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:40:14Z","timestamp":1786977614308,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>An intern doctor was found dead at their home with several signs of venepuncture. A bottle of propofol and a filled syringe appeared at the scene. Their medical history recorded antidepressant treatment and a suicide attempt 1.5\u2009years earlier by massive ingestion of venlafaxine and quetiapine. Toxicological investigation was requested to know previous history of drug use and to clarify the cause of death. A thorough chemical\u2010toxicological analysis of blood, urine, gastric contents, and syringe contents was performed by GC\u2010MS and LC\u2010Q\u2010TOF. A comprehensive qualitative screening of more than 500 drugs and toxins, as well as quantification of fentanyl, benzodiazepines, and propofol\u2010glucuronide, was carried out on three 3\u2010cm hair segments by LC\u2010MS\/MS. A high concentration of fentanyl was found in blood (38\u2009ng\/mL), together with nordiazepam (167\u2009ng\/mL), propofol (&lt;\u2009500\u2009ng\/mL), venlafaxine (630\u2009ng\/mL), and O\u2010desmethylvenlafaxine (510\u2009ng\/mL). Results in hair varied from distal to proximal to the root segment: fentanyl increased (43, 56, and 175\u2009pg\/mg, respectively); propofol\u2010glucuronide decreased (239, 73, and 37\u2009pg\/mg); and benzodiazepines increased. Venlafaxine and O\u2010desmethylvenlafaxine were positive in all three segments. These results revealed polydrug use for at least 9\u2009months prior to death and an increase in fentanyl use over this period. Segmental hair analysis uncovers patterns of drug misuse that improve the interpretation of postmortem results. Although death by suicide cannot be totally ruled out, the findings suggest accidental death by overdose of fentanyl in combination with other psychoactive drugs in a propofol and fentanyl abuser.<\/jats:p>","DOI":"10.1002\/dta.3851","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T05:14:48Z","timestamp":1738905288000},"page":"1601-1606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fentanyl and Propofol Misuse: Hair Analysis Provides Significant Evidence in the Death of a Young Doctor"],"prefix":"10.1002","volume":"17","author":[{"given":"M.\u00a0Jos\u00e9","family":"Burgue\u00f1o","sequence":"first","affiliation":[{"name":"National Institute of Toxicology and Forensic Sciences  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9\u00a0R.","family":"Bueno","sequence":"additional","affiliation":[{"name":"National Institute of Toxicology and Forensic Sciences  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Meg\u00eda","sequence":"additional","affiliation":[{"name":"National Institute of Toxicology and Forensic Sciences  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Quintela","sequence":"additional","affiliation":[{"name":"Toxicology Department Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"National Institute of Toxicology and Forensic Sciences  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Bravo","sequence":"additional","affiliation":[{"name":"National Institute of Toxicology and Forensic Sciences  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"375","article-title":"Abuse of Anesthetic Drugs by Anesthesiologists","volume":"62","author":"Jungerman F. 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