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Conventional analytical methods have limitations in terms of sensitivity and selectivity, and more precise techniques are time\u2010consuming and necessitate sample preparation. ASAP\u2010MS and DD\u2010SIMCA are two methods that have the potential to address these issues. This research delves into the efficacy of ASAP\u2010MS and DD\u2010SIMCA as a rapid and dependable approach for detecting ecstasy and its adulterants. PCA was conducted as an initial exploration, with the first three principal components (PCs) capturing 69% of the overall data variability. The score plot of PC1\u2009\u00d7\u2009PC3 revealed the distribution of samples containing MDA and MDMA. The DD\u2010SIMCA model exhibited high sensitivity in identifying the target samples (MDA) and relatively high specificity in training and test sets. These results underscore the effectiveness of ASAP\u2010MS, PCA, and DD\u2010SIMCA for precise identification of ecstasy and its adulterants, indicating their potential in drug identification and analysis. We observed that the chemometric model associated with ASAP\u2010MS was able to accurately identify, when compared to the results obtained by the standard technique, the constituents of ecstasy tablets, even in the presence of adulterants. Furthermore, the method could detect emerging psychoactive substances that are typically not targeted by traditional analytical approaches. These findings suggest that ASAP\u2010MS and DD\u2010SIMCA could be valuable tools in forensic drug analysis laboratories. The method is rapid, reliable, and versatile for identifying a wide range of ecstasy and its adulterants.<\/jats:p>","DOI":"10.1002\/dta.3860","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T02:14:20Z","timestamp":1738721660000},"page":"1567-1574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Robust Detection of Ecstasy\u2010Like and Adulterants Through ASAP\u2010MS and DD\u2010SIMCA"],"prefix":"10.1002","volume":"17","author":[{"given":"Rafael\u00a0D.","family":"Soares","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Quimiometria e Instrumenta\u00e7\u00e3o Anal\u00edtica (LAQIA), Instituto de Qu\u00edmica Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Rio Grande do Sul 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