{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:51:23Z","timestamp":1790661083260,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The abuse of oxycodone (OC) as a \u201crecreational\u201d drug has increased in the last two decades the risk of fatalities. We report two drug\u2010related deaths in which OC intoxication was considered the cause of death. Two brothers, a 19\u2010year\u2010old male (Subject 1) and a 27\u2010year\u2010old male (Subject 2), were found dead in their bedroom, lying on their beds. They were testified as alive in the morning, both deeply sleeping and loudly snoring in their beds; they were found dead later in the afternoon. On death scene investigation, two packs of 40\u2009mg OxyContin extended release and one alprazolam blister were found. The external examination was performed 72\u2009h after death with the collection of blood from femoral vein, vitreous humor, and urine samples. There were no trace of injection and no external signs of injury. A complete autopsy was performed 10\u2009days after death with the collection of peripheral blood from the femoral vein; central blood from the right ventricle; urine; gastric contents; and bile, adipose tissue, kidney, liver, brain, skeletal, and cardiac muscle tissue samples. The toxicological ascertainment evidenced the presence of OC, alprazolam, and bromazepam in fluids and tissues. For Subject 1, the concentration of OC in peripheral blood collected 72\u2009h after death (0.33\u2009mg\/L) was similar to the concentration in vitreous humor (0.41\u2009mg\/L); vitreous humor to peripheral blood ratio was 1.24. Ten days after death, OC levels were more than 10 times higher in peripheral blood (5.14\u2009mg\/L) and about six times higher compared to central blood specimen (1.78\u2009mg\/L), while OC levels in urine were, as expected, analogous. For Subject 2, OC concentration in peripheral blood collected 72\u2009h after death (0.50\u2009mg\/L) was similar to vitreous humor (0.87\u2009mg\/L). At Day 10 after death, OC levels were four times higher in peripheral blood (2.10\u2009mg\/L) while levels in central blood were lower (0.40\u2009mg\/L). OC concentration in urine was substantially similar at the two times of collection. OC levels in gastric contents were quite high (more than 50\u2009mg\/L). The analyses of specimens collected at two different times clearly demonstrate variation of blood OC concentrations with time. Postmortem redistribution from organs was also evidenced by high concentrations of OC in tissues such as the liver and kidney.<\/jats:p>","DOI":"10.1002\/dta.3862","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:09:13Z","timestamp":1739246953000},"page":"1614-1622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Postmortem Redistribution of Oxycodone"],"prefix":"10.1002","volume":"17","author":[{"given":"Beatrice","family":"Defraia","sequence":"first","affiliation":[{"name":"Forensic Medical Sciences, Department of Health Science University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Focardi","sequence":"additional","affiliation":[{"name":"Forensic Medical Sciences, Department of Health Science University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Aprile","sequence":"additional","affiliation":[{"name":"Legal Medicine and Toxicology University Hospital of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Vogliardi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5407-2160","authenticated-orcid":false,"given":"Ilenia","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Laboratory of Personal Identification and Forensic Morphology, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Menozzi","sequence":"additional","affiliation":[{"name":"Legal Medicine and Toxicology University Hospital of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donata","family":"Favretto","sequence":"additional","affiliation":[{"name":"Legal Medicine and Toxicology University Hospital of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20106576.1997.tb04684.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952\u20108180(96)00212\u20107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539\u2010199502000\u201000016"},{"key":"e_1_2_8_5_1","first-page":"72","article-title":"Oxycontin Abuse","volume":"99","author":"Suffett W. 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