{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:15:19Z","timestamp":1786947319037,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Infusing synthetic cannabinoid receptor agonists on paper quickly became a main route for illicit entry into prisons (i.e., mail correspondence) in the last decade. So far, there are limited data on validated detection methods and typical concentration profiles of these substances on paper to inform interventions. An approach to quantify and map the synthetic cannabinoid receptor agonist (SCRA) 5F\u2010MDMB\u2010PINACA on a seized paper sample from a UK Prison was determined using ultraperformance liquid chromatography\u2013mass spectrometry. The seized paper sample was initially screened using ultraperformance liquid chromatography\u2013quadrupole time\u2010of\u2010flight\u2013mass spectrometry that confirmed the presence of 5F\u2010MDMB\u2010PINACA. A quantification method was then optimised and validated for the SCRA using a simple liquid chromatography\u2013quadrupole Dalton\u2013mass spectrometry system. Percentage recovery studies were carried out on paper spiked with 1, 5 and 20\u2009mg\/cm<jats:sup>2<\/jats:sup> of 5F\u2010MDMB\u2010PINACA with five consecutive MeOH extractions. Results showed that one extraction recovered 83%\u201386%, while three extractions resulted in 98%\u201399% 5F\u2010MDMB\u2010PINACA recovery. Finally, the method was used to determine the concentration profile across the seized paper sample; 5F\u2010MDMB\u2010PINACA was in detectable amounts on all the paper subunits (<jats:italic>n<\/jats:italic>\u2009=\u200939) ranging between 0.26 and 55.13\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>, displaying a wide distribution of concentrations. Concentration profiles of SCRAs on seized paper samples are informative for interventions for those who are abusing or handling these substances in custodial settings but also provide key concentration ranges for those developing advanced methods of analysis in this area.<\/jats:p>","DOI":"10.1002\/dta.3864","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T05:30:13Z","timestamp":1738906213000},"page":"1607-1613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F\u2010MDMB\u2010PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography\u2013Mass Spectrometry Approaches"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-4952","authenticated-orcid":false,"given":"Giorgia","family":"Vaccaro","sequence":"first","affiliation":[{"name":"Department of Clinical, Pharmaceutical and Biological Science, School of Life and Medical Sciences University of Hertfordshire  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline\u00a0L.","family":"Stair","sequence":"additional","affiliation":[{"name":"Department of Clinical, Pharmaceutical and Biological Science, School of Life and Medical Sciences University of Hertfordshire  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart\u00a0B.","family":"Kirton","sequence":"additional","affiliation":[{"name":"Department of Clinical, Pharmaceutical and Biological Science, School of Life and Medical Sciences University of Hertfordshire  Hatfield UK"},{"name":"School of Applied and Health Science London South Bank University  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Clinical, Pharmaceutical and Biological Science, School of Life and Medical Sciences University of Hertfordshire  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Guirguis","sequence":"additional","affiliation":[{"name":"Department of Clinical, Pharmaceutical and Biological Science, School of Life and Medical Sciences University of Hertfordshire  Hatfield UK"},{"name":"Pharmacy Swansea University Medical School  Swansea Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3263"},{"key":"e_1_2_7_3_1","unstructured":"UNODC \u201cEarly Warning Advisory on New Psychoactive Substances. NPS Data Visualisations \u201dhttps:\/\/www.unodc.org\/LSS\/Page\/NPS\/DataVisualisation."},{"key":"e_1_2_7_4_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction \u201cNew Psychoactive Substances\u2014The Current Situation in Europe (European Drug Report 2024) \u201d (2024) https:\/\/www.euda.europa.eu\/publications\/european\u2010drug\u2010report\/2024\/new\u2010psychoactive\u2010substances_en."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsisyn.2020.11.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105691"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2023.104219"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcop.22989"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2024.111991"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419\u2010021\u201000586\u20107"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3351"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3817"},{"key":"e_1_2_7_13_1","volume-title":"Strategies to Prevent Contraband Smuggling in Correctional Facilities (NIJ Grant No. 302140)","author":"National Institute of Justice","year":"2021"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2767"},{"key":"e_1_2_7_15_1","unstructured":"V.Angerer C.M\u00f6ller andV.Auw\u00e4rter \u201cSynthetic Cannabinoids in Prisons\u2014Invisibly Impregnated Paper Sheets as a Trojan Horse\u201d (poster presentation International Association of Forensic Toxicologists (TIAFT) Conference Ghent Belgium 2018) https:\/\/www.uniklinik\u2010freiburg.de\/fileadmin\/mediapool\/08_institute\/rechtsmedizin\/pdf\/Poster_2018\/Angerer_V_\u2010_Tiaft_2018.pdf."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2945"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c01844"},{"key":"e_1_2_7_18_1","volume-title":"Guidance for the Validation of Analytical Methodology and Calibration of Equipment Used for Testing of Illicit Drugs in Seized Materials and Biological Specimens: A Commitment to Quality and Continuous Improvement","author":"United Nations Office on Drugs and Crime, Laboratory and Scientific Section","year":"2009"},{"key":"e_1_2_7_19_1","volume-title":"Guidelines on Representative Drug Sampling","author":"United Nations Office on Drugs and Crime, Laboratory and Scientific Section, European Network of Forensic Science Institutes, Drugs Working Group","year":"2009"},{"key":"e_1_2_7_20_1","first-page":"51","volume-title":"Analysis and Interpretation of Freshwater Fisheries Data","author":"Hansen M. J.","year":"2007"},{"key":"e_1_2_7_21_1","unstructured":"UK Home Office \u201cAnnual Report on the Home Office Forensic Early Warning System (FEWS): 2021 to 2022 \u201d (2022) https:\/\/www.gov.uk\/government\/publications\/forensic\u2010early\u2010warning\u2010system\u2010fews\u2010annual\u2010report\/annual\u2010report\u2010on\u2010the\u2010home\u2010office\u2010forensic\u2010early\u2010warning\u2010system\u2010fews\u20102021\u2010to\u20102022#executive\u2010summary."},{"key":"e_1_2_7_22_1","volume-title":"Risk Assessment of Methyl 2\u2010{[1\u2010(5\u2010fluoropentyl)\u20101H\u2010indazole\u20103\u2010carbonyl]amino}\u20103,3\u2010dimethylbutanoate (5F\u2010MDMB\u2010PINACA)","author":"European Monitoring Centre for Drugs and Drug Addiction","year":"2018"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.3864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:37:46Z","timestamp":1761032266000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.3864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/dta.3864"],"URL":"https:\/\/doi.org\/10.1002\/dta.3864","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"value":"1942-7603","type":"print"},{"value":"1942-7611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,7]]},"assertion":[{"value":"2024-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}