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Because the first generation of antihistamines was shown to seriously impair cognitive psychomotor and driving performance in healthy volunteers, the aim of our research was to determine the effect of DMH by testing physical activity and cognitive and cardiovascular functions using an animal model to identify a possible stimulatory effect. The study protocol consisted of two phases. The first was designed to analyze the stimulating motor effect of DMH. Four study groups were formed: (1) vehicle (Veh), (2) modafinil (MOD), (3) DMH at 50\u2009mg\/kg (DMH\u201050), and (4) DMH at 200\u2009mg\/kg (DMH\u2010200). Motor coordination and balance, physical activity, hemodynamics, and nitrous oxide (NO) quantification were performed. In the second phase, we sought to discriminate the compound in DMH that generates the stimulating effect. In this case, the study groups were (1) Veh, (2) MOD, (3) DMH, (4) diphenhydramine (DPH), (5) 8\u2010chlorotheophylline (8\u2010Cl\u2010T), and (6) theophylline (TEO). In this phase, we quantified glucose and insulin levels, behavior, physical activity, blood pressure, and vascular reactivity to phenylephrine and acetylcholine. Findings showed that DMH might improve a motor and physical stimulating effect but also increased NO levels in the lungs. DPH promoted a compulsive\u2010like behavior that diminished with 8\u2010Cl\u2010T. Regarding cardiovascular effects, DMH decreased vascular reactivity to phenylephrine and acetylcholine. Finally, in the DMH formulation, 8\u2010Cl\u2010T was identified as the compound responsible for increasing blood pressure and heart rate.<\/jats:p>","DOI":"10.1002\/dta.3875","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:18:39Z","timestamp":1741713519000},"page":"1750-1758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Dimenhydrinate on Motor Behavior and Vascular Function: Possible Implications for the Field of Sports"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0431-5427","authenticated-orcid":false,"given":"Jazm\u00edn","family":"Flores\u2010Monroy","sequence":"first","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda del Miocardio, Facultad de Estudios Superiores Cuautitl\u00e1n Universidad Nacional Aut\u00f3noma de M\u00e9xico  Cuautitl\u00e1n Izcalli Estado de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5624-1693","authenticated-orcid":false,"given":"Diana","family":"Ram\u00edrez\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda del Miocardio, Facultad de Estudios Superiores Cuautitl\u00e1n Universidad Nacional Aut\u00f3noma de M\u00e9xico  Cuautitl\u00e1n Izcalli Estado de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-3736","authenticated-orcid":false,"given":"Diego","family":"Lezama\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda del Miocardio, Facultad de Estudios Superiores Cuautitl\u00e1n Universidad Nacional Aut\u00f3noma de M\u00e9xico  Cuautitl\u00e1n Izcalli Estado de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2934-8698","authenticated-orcid":false,"given":"Benjam\u00edn","family":"Velasco\u2010Bejarano","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Medicinal Verde, Facultad de Estudios Superiores Cuautitl\u00e1n Universidad Nacional Aut\u00f3noma de M\u00e9xico  Cuautitl\u00e1n Izcalli Estado de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256\u2010199315030\u201000004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.36834\/cmej.69739"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199203000-00015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(68)91735\u20102"},{"key":"e_1_2_9_6_1","first-page":"336","article-title":"American Health Programme","volume":"96","author":"Hardman A. 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