{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:27:59Z","timestamp":1787063279748,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001139","name":"ACT Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    2\u2010Benzylbenzimidazole opioids and related derivatives, also known as \u2018nitazenes\u2019, present a growing threat to public health. Emerging in Europe in 2019, the nitazene group of drugs is a recent addition to the novel synthetic opioid class and has been associated internationally with adverse effects in drug users, overdose clusters and significant mortality. The high potency of many nitazene derivatives, which can in many cases exceed that of fentanyl, poses a significant challenge to the public health and early warning systems used to detect and respond to the emergence of new high\u2010risk substances. This report describes close collaboration between an Australian drug checking service and a nearby university laboratory to identify and characterise the novel synthetic opioid\n                    <jats:italic>N<\/jats:italic>\n                    \u2010pyrrolidino isotonitazene in an expected oxycodone sample presented by a member of the public. Though no prior publications are available describing the presence of this nitazene in the drug market, previously reported in\u00a0vitro evaluation of this compound reveals it to be among the most potent nitazene opioid agonists known. The study highlights the rapid response possible though engaging drug users with drug checking services as a market monitor and early warning system to alert health services and the broader community to the presence of unexpected, high\u2010risk substances. Integration of well\u2010resourced and supported drug checking services provides a powerful approach to tackle the public health threats associated with novel synthetic opioids and other drugs of concern.\n                  <\/jats:p>","DOI":"10.1002\/dta.3910","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T05:05:09Z","timestamp":1747631109000},"page":"1996-2004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Identification of the Novel Synthetic Opioid\n                    <i>N<\/i>\n                    \u2010Pyrrolidino Isotonitazene at an Australian Drug Checking Service"],"prefix":"10.1002","volume":"17","author":[{"given":"Blake","family":"Curtis","sequence":"first","affiliation":[{"name":"Research School of Chemistry Australian National University  Canberra Australian Capital Territory Australia"},{"name":"CanTEST Health and Drug Checking Service  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas\u00a0J.","family":"Lawes","sequence":"additional","affiliation":[{"name":"Research School of Chemistry Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Caldicott","sequence":"additional","affiliation":[{"name":"Emergency Department North Canberra Hospital  Canberra Australian Capital Territory Australia"},{"name":"School of Medicine and Psychology Australian National University  Canberra Australian Capital Territory Australia"},{"name":"The Australian Drug Observatory Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-3226","authenticated-orcid":false,"given":"Malcolm\u00a0D.","family":"McLeod","sequence":"additional","affiliation":[{"name":"Research School of Chemistry Australian National University  Canberra Australian Capital Territory Australia"},{"name":"The Australian Drug Observatory Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2738"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00037"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00064"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00750"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.123.002052"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010024\u201003774\u20107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkaa016"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2021.110686"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkab082"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000970"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkac062"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3707"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16525"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3637"},{"key":"e_1_2_8_16_1","unstructured":"A.Olsen G.Baillie R.Bruno D.McDonald M.Hammoud andA.Peacock \u201cCanTEST Health and Drug Checking Service Program Evaluation: Final Report \u201d accessed March 19 2024 (2023) Australian National University https:\/\/health.act.gov.au\/sites\/default\/files\/2023\u201007\/CanTEST%20Final%20Evaluation%20Report_2023.pdf."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forc.2024.100605"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3113"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40736"},{"key":"e_1_2_8_20_1","unstructured":"N.Man R.Sutherland V.Sadaphale M.Barratt R.Bruno andA.Peacock \u201cTrends in the Availability and Types of Drugs Sold on the Internet via Cryptomarkets October 2023\u2013September 2024; 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