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A total of 21 voluntary participants (aged 31\u201369\u2009years) took part in a 2\u2010week drinking study. Group 1 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200911) consumed one glass of wine daily (16\u2009g of alcohol), close to the present Swedish limit for hazardous alcohol consumption, while Group 2 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) consumed two glasses daily (32\u2009g of alcohol). Alcohol biomarkers were measured at baseline and at three further occasions during the study. After 1\u2009week of alcohol consumption, all participants had measurable concentrations (&gt;\u20090.005\u2009\u03bcmol\/L, \u22483.5\u2009ng\/mL) of both PEth\u2010homologues (PEth 16:0\/18:1 and PEth 16:0\/18:2). After 1\u2010 and 2\u2010week periods, significant differences in PEth levels were observed between Group 1 and Group 2. The correlation between the two PEth\u2010homologues was strong and increased as the study progressed. In contrast, other biomarkers showed little to no change during the study period. Both PEth\u2010homologues appear capable of identifying hazardous alcohol consumption. The current Swedish reporting threshold for PEth 16:0\/18:1 (0.05\u2009\u03bcmol\/L, \u224835\u2009ng\/mL) demonstrates high specificity but low sensitivity in identifying hazardous alcohol consumption involving regular\/daily intake. The sensitivity of the other biomarkers is insufficient for detecting alcohol consumption at this level.\n                  <\/jats:p>","DOI":"10.1002\/dta.3970","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T23:18:58Z","timestamp":1763507938000},"page":"108-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PEth Cut\u2010Off Thresholds for Hazardous Alcohol Consumption Based on a Drinking Study"],"prefix":"10.1002","volume":"18","author":[{"given":"Lisa","family":"Walther","sequence":"first","affiliation":[{"name":"Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine Lund University  Lund Sweden"},{"name":"Department of Clinical Chemistry and Pharmacology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Stenton","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Pharmacology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Pharmacology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Blomgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Pharmacology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Pharmacology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-3139","authenticated-orcid":false,"given":"Anders","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine Lund University  Lund Sweden"},{"name":"Department of Clinical Chemistry and Pharmacology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Global Status Report on Alcohol and Health and Treatment of Substance Use Disorders. 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