{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:02:21Z","timestamp":1773392541382,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic exposure to pesticides can cause carcinogenic, reproductive, neurological, and endocrine\u2010disrupting effects. Hair analysis is a valuable biomonitoring tool to assess human exposure to pesticides. We determined the presence of pesticides, their metabolites, and other environmental pollutants in the hair of children in an agricultural area of Paraguay. We analyzed 152 pesticides and environmental chemicals in hair samples from 51 children (2\u201314\u2009years, mean\u2009\u00b1\u2009SD\u2009=\u20098.5\u2009\u00b1\u20093.3\u2009years) living in Colonia San Juan, a rural community in Paraguay. The locality is surrounded by soybean crops, and the community engages primarily in family farming. Eighty of the 152 compounds (52.6%) were detected. Each child's sample contained an average of 55\u2009\u00b1\u20093.7 compounds (range 48\u201365), including organophosphates, pyrethroids, neonicotinoids, fungicides, herbicides, and endocrine disruptors such as bisphenol A and bisphenol S. Thirty\u2010seven compounds were present in all samples. Children in this rural community are simultaneously exposed to numerous pesticides and pollutants, highlighting the urgent need for stricter environmental protections and preventive health measures.<\/jats:p>","DOI":"10.1002\/dta.70020","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T07:07:01Z","timestamp":1766819221000},"page":"354-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pesticide Contamination in the Hair of Children From Colonia San Juan, a Rural Community in Paraguay"],"prefix":"10.1002","volume":"18","author":[{"given":"Stela","family":"Benitez\u00a0Leite","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad Cat\u00f3lica Nuestra Se\u00f1ora de la Asunci\u00f3n  Asunci\u00f3n Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Iglesias\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Human Biomonitoring Research Unit, Department of Precision Health Luxembourg Institute of Health  Strassen Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirta\u00a0Noem\u00ed","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Hospital General Pediatrico Ni\u00f1os de Acosta \u00d1u  San Lorenzo Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u00a0Luisa","family":"Macchi","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad Cat\u00f3lica Nuestra Se\u00f1ora de la Asunci\u00f3n  Asunci\u00f3n Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1732-4741","authenticated-orcid":false,"given":"Robin","family":"Mesnage","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brice\u00a0M.\u00a0R.","family":"Appenzeller","sequence":"additional","affiliation":[{"name":"Human Biomonitoring Research Unit, Department of Precision Health Luxembourg Institute of Health  Strassen Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2542\u20105196(22)00090\u20100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010020\u201008754\u20109"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/03601234.2019.1654808"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/19393210.2019.1675779"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010019\u201006550\u20108"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.13031\/jash.13065"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09603123.2021.1987396"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010022\u201003229\u2010y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP12097"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh\u20102018\u20100070"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12030189"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010016\u20101910\u20109"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106481"},{"key":"e_1_2_10_15_1","unstructured":"Servicio Nacional de Calidad y Sanidad Vegetal y de Semillas (SENAVE). \u201cAnuario 2007 [Internet] \u201d Asunci\u00f3n Paraguay: Secretar\u00eda de Planificaci\u00f3n e Inform\u00e1tica;2007[cited 2024 September 7] https:\/\/www.senave.gov.py\/docs\/publicaciones\/anuarios\/anuario2007.pdf."},{"key":"e_1_2_10_16_1","unstructured":"C\u00e1mara Paraguaya de Exportadores y Comercializadores de Cereales y Oleaginosas (CAPECO). \u201cEstudio Satelital [Internet] \u201d CAPECO. [cited 2024 September 7] https:\/\/capeco.org.py\/soja\u2010satelital\u2010es\/c."},{"key":"e_1_2_10_17_1","unstructured":"C\u00e1mara Paraguaya de Exportadores y Comercializadores de Cereales y Oleaginosas (CAPECO). \u201c\u00c1rea de Siembra Producci\u00f3n y Rendimiento [Internet] \u201d CAPECO. [cited 2024 September 7] https:\/\/capeco.org.py\/area\u2010de\u2010siembra\u2010produccion\u2010y\u2010rendimiento\/."},{"key":"e_1_2_10_18_1","unstructured":"C\u00e1mara Paraguaya de Exportadores y Comercializadores de Cereales y Oleaginosas (CAPECO). \u201cRanking Mundial [Internet] \u201d CAPECO. [cited 2024 September 7] https:\/\/capeco.org.py\/ranking\u2010mundial\u2010es\/."},{"key":"e_1_2_10_19_1","unstructured":"\u201cEOM\u2010 Statement\u2010SR\u2010Toxics\u2010Paraguay\u201014\u2010Oct\u20102022\u2010EN.pdf \u201d (accessed 15 November 2022). Available fromhttps:\/\/www.ohchr.org\/sites\/default\/files\/documents\/issues\/toxicwaste\/2022\u201010\u201014\/."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1497_17"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1649"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.07.023"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11110896"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2019.04.005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.12.043"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105332"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207233.2023.2170644"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207233.2024.2330274"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12403\u2010021\u201000444\u20102"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2016.02.016"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2020.1787330"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh\u20102022\u20100092"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010023\u201030080\u2010z"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.118222"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2022.113316"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP11380"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.104997"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1274724"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2023.10.001"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2022.113935"},{"key":"e_1_2_10_41_1","unstructured":"International Agency for Research on Cancer World Health Organization. \u201cDDT Lindane and 2 4\u2010D [Internet]. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans \u201d2016[cited 2024 September 7] https:\/\/publications.iarc.fr\/Book\u2010And\u2010Report\u2010Series\/Iarc\u2010Monographs\u2010On\u2010The\u2010Identification\u2010Of\u2010Carcinogenic\u2010Hazards\u2010To\u2010Humans\/DDT\u2010Lindane\u2010And\u20102\u20104\u2010D\u20102016."},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11112882"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocon.2019.01.020"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2022.105446"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.01.059"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010022\u201019745\u20103"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106433"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010023\u201003614\u20100"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14132766"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2023.6857"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108881"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107342"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.122705"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.70020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dta.70020","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.70020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:21:18Z","timestamp":1773386478000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.70020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/dta.70020"],"URL":"https:\/\/doi.org\/10.1002\/dta.70020","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"value":"1942-7603","type":"print"},{"value":"1942-7611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]},"assertion":[{"value":"2025-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}