{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:12:15Z","timestamp":1792977135928,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This paper describes the detection and longitudinal monitoring of cyclosporine in plasma and urine after subconjunctival implant administration in a horse. Sensitive liquid chromatography tandem mass spectroscopy (LC\u2013MS\/MS) methods for detecting cyclosporine in horse plasma and urine have been developed and validated, with estimated limits of detection down to 1\u2009pg\/mL in both matrices. The developed methods enabled longitudinal monitoring of cyclosporine levels in blood and urine samples collected over 6 months from a horse that had received an ocular cyclosporine implant.<\/jats:p>","DOI":"10.1002\/dta.70026","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:14:47Z","timestamp":1768792487000},"page":"376-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Detection and Longitudinal Monitoring of Cyclosporine in Horse Plasma and Urine After Ocular Implant Administration"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0015-781X","authenticated-orcid":false,"given":"Yat\u2010Ming","family":"So","sequence":"first","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5239-7079","authenticated-orcid":false,"given":"Wai\u00a0Him","family":"Kwok","sequence":"additional","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlynn","family":"Yap","sequence":"additional","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia\u00a0O.\u00a0L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel\u00a0G.\u00a0R.","family":"Smalley","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Services The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronte\u00a0S.","family":"Forbes","sequence":"additional","affiliation":[{"name":"Veterinary Regulation, Welfare and Biosecurity Policy The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek\u00a0W.\u00a0Y.","family":"Chow","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Hospital  Wan Chai Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-2066","authenticated-orcid":false,"given":"Emmie\u00a0N.\u00a0M.","family":"Ho","sequence":"additional","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club, Sha Tin Racecourse  Sha Tin Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01211\u201018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/230386"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101525"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.21836\/PEM20110603"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20103083.2003.01221.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2009.00740.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.14213"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12087"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.06.054"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0272\u20106386(86)80106\u20108"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00072.2007"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2290"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010015\u20109145\u20109"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.05.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2010.00807.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1892"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1263"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.03.032"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202308251"},{"key":"e_1_2_8_21_1","unstructured":"Association of the Official Racing Chemists \u201cGuidelines for the Minimum Criteria for Identification by Chromatography and Mass Spectrometry \u201dhttps:\/\/www.aorc\u2010online.org\/documents\/aorc\u2010ms\u2010criteria\u2010ilacg7\/. Accessed October 23 2025."}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.70026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dta.70026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.70026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:21:32Z","timestamp":1773386492000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.70026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,18]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/dta.70026"],"URL":"https:\/\/doi.org\/10.1002\/dta.70026","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"value":"1942-7603","type":"print"},{"value":"1942-7611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,18]]},"assertion":[{"value":"2025-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}