{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:59:07Z","timestamp":1791525547713,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502277"],"award-info":[{"award-number":["82502277"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The nonmedical use of etomidate and its structural analogs as additives in e\u2010cigarettes has shown a significant growth trend, and the public health and safety risks arising from the abuse of such substances have drawn widespread attention. This study comprehensively employed gas chromatography\u2013mass spectrometry, liquid chromatography\u2013high\u2010resolution mass spectrometry, and nuclear magnetic resonance spectroscopy (NMR) techniques to identify a novel metomidate analog, 4\u2010fluorometomidate, in seized cartridges for the first time. Mass spectrometry analysis revealed that under electron ionization conditions, the compound produced fragment ions at\n                    <jats:italic>m\/z<\/jats:italic>\n                    77.1, 95.1, 103.1, 123.1, and 248.1. The molecular ion (\n                    <jats:italic>m\/z<\/jats:italic>\n                    248.1) and base peak (\n                    <jats:italic>m\/z<\/jats:italic>\n                    123.1) were both 18\u2009Da higher than the corresponding peaks (\n                    <jats:italic>m\/z<\/jats:italic>\n                    230.1 and 105.1) characteristic for metomidate. In electrospray ionization mode, its protonated molecule (\n                    <jats:italic>m\/z<\/jats:italic>\n                    249.1032) also exhibited an increase of 17.9908\u2009Da compared to metomidate (\n                    <jats:italic>m\/z<\/jats:italic>\n                    231.1124), and the characteristic fragment at\n                    <jats:italic>m\/z<\/jats:italic>\n                    123.0607 showed an increase of 17.9909\u2009Da relative to the fragment of metomidate (\n                    <jats:italic>m\/z<\/jats:italic>\n                    105.0698), which was overall consistent with the substitution of one hydrogen atom by a fluorine atom (\u25b3\n                    <jats:italic>m\/z<\/jats:italic>\n                    17.9905). NMR analysis confirmed that the fluorine atom is located at the 4\u2032\u2010position of the benzene ring.\n                  <\/jats:p>","DOI":"10.1002\/dta.70070","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T23:49:59Z","timestamp":1775432999000},"page":"750-755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structural Characterization of 4\u2010Fluorometomidate: A Novel Metomidate Derivative Detected in an E\u2010Cigarette"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8662-7043","authenticated-orcid":false,"given":"Jialin","family":"Feng","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine Academy of Forensic Science  Shanghai People's Republic of China"},{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine Academy of Forensic Science  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6309-642X","authenticated-orcid":false,"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine Academy of Forensic Science  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9665-4292","authenticated-orcid":false,"given":"Ping","family":"Xiang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine Academy of Forensic Science  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8217-4965","authenticated-orcid":false,"given":"Junbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine Academy of Forensic Science  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/yco.0000000000000612"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2019.02.021"},{"key":"e_1_2_10_4_1","unstructured":"European Drug Report 2025: Trends and Developments \u00a0accessed June 6 2025 https:\/\/www.euda.europa.eu\/publications\/european\u2010drug\u2010report\/2025_en."},{"key":"e_1_2_10_5_1","unstructured":"United Nations Office on Drugs and Crime2025October 2025\u2014UNODC EWA: Record High of 688 Individual NPS Reported Worldwide in 2024 accessed October 13 2025 https:\/\/www.unodc.org\/LSS\/Announcement\/Details\/d748996b\u201012a9\u20104236\u20108be9\u20108b0d40eab2d6."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1614865"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000434"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01981448"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419\u2010024\u201000698\u2010w"},{"issue":"6","key":"e_1_2_10_10_1","first-page":"626","article-title":"Forensic Identification of Death Caused by Etomidate Overdose: A Case Report","volume":"39","author":"Zhao S. 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