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Mane hair samples were collected at 172\u2010 and 217\u2010day post\u2010implantation and analysed by liquid chromatography\u2013tandem mass spectrometry (LC\u2010MS\/MS) after alkaline hydrolysis and liquid\u2013liquid extraction. The method achieved an estimated limit of detection of 0.1\u2009pg\/mg. Cyclosporine was detected in hair at both sampling time points, with segmental analysis revealing distribution patterns consistent with systemic exposure and incorporation during hair growth. Peak concentrations were observed in distal segments corresponding to the period of implantation, whereas proximal segments in the later sample were below the detection limit, indicating declining exposure over time. To our knowledge, this study provides the first evidence of an exogenous peptide drug being incorporated into equine hair. The prolonged detectability of cyclosporine in hair highlights its potential as a complementary matrix for long\u2010term monitoring of peptide drug exposure in equine sports.<\/jats:p>","DOI":"10.1002\/dta.70132","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T05:44:52Z","timestamp":1786167892000},"page":"1346-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection of Cyclosporine in Horse Hair After Ocular Implant Administration"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5830-4797","authenticated-orcid":false,"given":"Ian\u00a0P.\u00a0Y.","family":"Lam","sequence":"first","affiliation":[{"name":"Racing Laboratory The Hong Kong Jockey Club  Sha Tin Hong Kong, 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