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Since late 2022, products marketed as \u201c1D\u2010LSD\u201d have been advertised on X (formerly Twitter) and other websites. Despite various online references portraying 1D\u2010LSD as 1\u2010(1,2\u2010dimethylcyclobutane\u20101\u2010carbonyl)\u2010LSD, our chemical analysis of a product marketed as \u201c1D\u2010LSD\u201d revealed that it actually contained 1\u2010(thiophene\u20102\u2010carbonyl)\u2010LSD (1T\u2010LSD), which has the same nominal mass. Another group subsequently reported similar findings in a blotter paper printed \u201c1D\u2010LSD.\u201d. In this study, we synthesized 1D\u2010LSD as a mixture of four diastereomers, reflecting the stereoisomers of the commercially available 1,2\u2010dimethylcyclobutane\u20101\u2010carboxylic acid. The mixture was separated into two groups, each consisting of two diastereomers, through preparative liquid chromatography. The correspondence between the fractions and diastereomers was established using nuclear magnetic resonance spectroscopy aided by quantum chemical calculations. The synthesized 1D\u2010LSD was further characterized using liquid chromatography\/mass spectrometry, gas chromatography\/mass spectrometry, and Fourier\u2010transform infrared spectroscopy. Additionally, the incorporated carboxylic acid was recovered through alkaline hydrolysis, and analysis of the recovered acid confirmed the presence of all four diastereomers. The analytical properties of 1D\u2010LSD were compared with those of 1T\u2010LSD. Our comparative analysis revealed that the two compounds exhibited markedly different analytical properties, indicating that confusion between them is unlikely when appropriate analytical methods are applied.<\/jats:p>","DOI":"10.1002\/dta.70139","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:50:21Z","timestamp":1787817021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Analytical Characterization of 1\u2010(1,2\u2010Dimethylcyclobutane\u20101\u2010Carbonyl)\u2010Lysergic Acid Diethylamide (1D\u2010LSD) and Differentiation From 1\u2010(Thiophene\u20102\u2010Carbonyl)\u2010LSD (1T\u2010LSD)"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1026-1591","authenticated-orcid":false,"given":"Yuki","family":"Okada","sequence":"first","affiliation":[{"name":"Third Department of Forensic Science National Research Institute of Police Science  Kashiwa Chiba Japan"},{"name":"Graduate School of Pharmaceutical Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5880-2466","authenticated-orcid":false,"given":"Tadashi","family":"Yamamuro","sequence":"additional","affiliation":[{"name":"Third Department of Forensic Science National Research Institute of Police Science  Kashiwa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0782-8842","authenticated-orcid":false,"given":"Kenji","family":"Kuwayama","sequence":"additional","affiliation":[{"name":"Third Department of Forensic Science National Research Institute of Police Science  Kashiwa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1380-9565","authenticated-orcid":false,"given":"Kenji","family":"Tsujikawa","sequence":"additional","affiliation":[{"name":"Third Department of Forensic Science National Research Institute of Police Science  Kashiwa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7570-0720","authenticated-orcid":false,"given":"Tatsuyuki","family":"Kanamori","sequence":"additional","affiliation":[{"name":"Third Department of Forensic Science National Research Institute of Police Science  Kashiwa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2432-5179","authenticated-orcid":false,"given":"Yuko T.","family":"Iwata","sequence":"additional","affiliation":[{"name":"Third Department of Forensic Science National Research Institute of Police Science  Kashiwa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-4735","authenticated-orcid":false,"given":"Naoyuki","family":"Toriumi","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6385-5944","authenticated-orcid":false,"given":"Masanobu","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19430260326"},{"key":"e_1_2_8_3_1","unstructured":"EMCDDA\u2010Europol \u201cAnnual Report on the Implementation of Council Decision 2005\/387\/JHA \u201d (2016) https:\/\/www.euda.europa.eu\/system\/files\/media\/publications\/documents\/4724\/TDAN17001ENN_PDFWEB.pdf."},{"key":"e_1_2_8_4_1","unstructured":"EMCDDA\u2010Europol \u201cAnnual Report on the Implementation of Council Decision 2005\/387\/JHA \u201d (2017) 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