{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:07:37Z","timestamp":1788829657865,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The use of pre\u2010precursors to illicitly manufacture 3,4\u2010methylenedioxyphenyl\u20102\u2010propanone (MDP2P) for the synthesis of 3,4\u2010methylenedioxymethylamphetamine (MDMA) has emerged in clandestine laboratories. Methyl 3\u2010(3,4\u2010methylenedioxyphenyl)\u20102\u2010methyl glycidate (MMDMG) and ethyl 3\u2010(3,4\u2010methylenedioxyphenyl)\u20102\u2010methyl glycidate (EMDMG) have recently been seized in clandestine laboratories in New South Wales, Australia. These glycidate esters can be converted to MDP2P via acid or base hydrolysis. This study investigated factors influencing MDP2P yield from MMDMG and EMDMG through both pathways. For acid hydrolysis, hydrochloric, sulphuric, phosphoric and acetic acids were examined at different reaction times and temperatures. Reactions at 100\u00b0C produced higher MDP2P yields than those at room temperature, and 18\u2009h was sufficient for complete conversion. Hydrochloric and sulphuric acids gave the highest yields after 18\u2009h at 100\u00b0C (79% and 78%, respectively), phosphoric acid gave moderate conversion (~30%), and acetic acid produced poor yields (&lt;\u200910%). The conversion proceeded via two previously unreported diol\u2010ester intermediates. Base hydrolysis involved heating glycidate esters with sodium hydroxide in alcohol, forming sodium piperonyl methyl ketone (PMK) glycidate, followed by reaction with aqueous acid. Heating MMDMG in methanol or EMDMG in ethanol for 5\u2009h produced sodium PMK glycidate. This intermediate was unstable in acidic aqueous solution and rapidly converted to MDP2P at room temperature. Yields obtained using hydrochloric, sulphuric and phosphoric acids (73%, 71% and 69%, respectively) were comparable to acid hydrolysis, whereas acetic acid produced lower yields (25%). This work may assist law enforcement agencies to predict illicit drug yields from pre\u2010precursors and support investigations into emerging illicit drug synthesis trends.<\/jats:p>","DOI":"10.1002\/dta.70143","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:20:11Z","timestamp":1788826811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Investigation Into the Yields of 3,4\u2010Methylenedioxyphenyl\u20102\u2010propanone (MDP2P) From Glycidate Pre\u2010Precursors"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9378-9568","authenticated-orcid":false,"given":"Alexandra L.","family":"Mercieca","sequence":"first","affiliation":[{"name":"School of Mathematical and Physical Sciences University of Technology Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella S.","family":"Schuett","sequence":"additional","affiliation":[{"name":"School of Mathematical and Physical Sciences University of Technology Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9502-1175","authenticated-orcid":false,"given":"Andrew M.","family":"McDonagh","sequence":"additional","affiliation":[{"name":"School of Mathematical and Physical Sciences University of Technology Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6238-3612","authenticated-orcid":false,"given":"Shanlin","family":"Fu","sequence":"additional","affiliation":[{"name":"Centre for Forensic Science, School of Mathematical and Physical Sciences University of Technology Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6308-1635","authenticated-orcid":false,"given":"Morgan","family":"Alonzo","sequence":"additional","affiliation":[{"name":"School of Mathematical and Physical Sciences University of Technology Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3256"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3946"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3140"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2024.112315"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo50013a017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01110a013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00832a021"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00883a038"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/JR9430000015"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556\u20104029.2007.00480.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00450618.2026.2615334"},{"key":"e_1_2_8_13_1","volume-title":"Precursors, Chemicals and Equipment Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances 2025","author":"International Narcotics Control Board","year":"2025"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo0607966"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11176\u2010005\u20100241\u2010y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","DOI":"10.59161\/Rapport202302","volume-title":"Internal Standard Reference Data for qNMR: Benzoic Acid [ISRD\u201008]","author":"Zhang W.","year":"2023"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2006.05.021"},{"key":"e_1_2_8_18_1","volume-title":"SWGDRUG Recommendations Version 8.2","author":"Scientific Working Group for the Analysis of Seized Drugs (Swgdrug)","year":"2024"},{"key":"e_1_2_8_19_1","volume-title":"Eurachem Guide: The Fitness for Purpose of Analytical Methods\u2014A Laboratory Guide to Method Validation and Related Topics","author":"Cantwell H.","year":"2025"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2020.110332"},{"key":"e_1_2_8_21_1","volume-title":"PMK Ethyl Glycidate NPS Discovery New Drug Monograph, United States: Center for Forensic Science Research and Education","author":"Walton S.","year":"2024"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2008.04.009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/chin.198852067"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo702401t"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2686"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.70143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dta.70143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.70143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:20:13Z","timestamp":1788826813000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.70143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":24,"alternative-id":["10.1002\/dta.70143"],"URL":"https:\/\/doi.org\/10.1002\/dta.70143","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"value":"1942-7603","type":"print"},{"value":"1942-7611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]},"assertion":[{"value":"2026-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dta.70143"}}