{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:28:57Z","timestamp":1793665737254,"version":"4.5.1"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Methiodone (IC\u201026) is a non\u2010fentanyl novel synthetic opioid which has recently been detected in drug seizures in Europe. There is still limited data about the drug in published toxicological case work, both in non\u2010fatal and fatal cases. We present a medicolegal autopsy case report on a fatal intoxication in an individual undergoing opioid agonist treatment. A methiodone concentration of 1.5\u2009mg\/L was detected in the femoral vein blood and was considered the primary intoxicant causing death. This is the first published occurrence of fatal intoxication involving methiodone in Finland and emphasizes the need for constant monitoring of substance abuse during substitution therapy, including the potential use of novel synthetic opioids.<\/jats:p>","DOI":"10.1002\/dta.70148","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:52:12Z","timestamp":1789192332000},"page":"1486-1489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First Occurrence of Fatal Intoxication Involving Methiodone (IC\u201026) in Finland; a Medicolegal Autopsy Case Report"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-7652","authenticated-orcid":false,"given":"Lasse","family":"Pakanen","sequence":"first","affiliation":[{"name":"Forensic Medicine Unit Finnish Institute for Health and Welfare  Oulu Finland"},{"name":"Research Unit of Biomedicine and Internal Medicine, Medical Research Center (MRC) Oulu University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4402-2370","authenticated-orcid":false,"given":"Raimo\u00a0A.","family":"Ketola","sequence":"additional","affiliation":[{"name":"Forensic Chemistry Unit Finnish Institute for Health and Welfare  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5721-2827","authenticated-orcid":false,"given":"Pirkko","family":"Kriikku","sequence":"additional","affiliation":[{"name":"Forensic Chemistry Unit Finnish Institute for Health and Welfare  Helsinki Finland"},{"name":"Department of Forensic Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000324"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkae062"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16020177"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102025\u20101428"},{"key":"e_1_2_7_6_1","unstructured":"E. J.Smolders T.Klein B.van deVelde et\u00a0al. \u201cMethiodone (IC\u201026): an emerging designer opioid causing severe toxicity \u201d [conference presentation]. NAFT Annual Meeting Stockholm Sweden (May 6\u20108 2026)."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxac.2026.03.047"},{"key":"e_1_2_7_8_1","unstructured":"Die Bayerische Polizei \u201cErneute Todesf\u00e4lle und Intoxikationen in Zusammenhang mit \u201dForschungschemikalien\u201d \u201d accessed May 15 2026 https:\/\/www.polizei.bayern.de\/aktuelles\/pressemitteilungen\/093264\/index.html."},{"key":"e_1_2_7_9_1","unstructured":"\u201cAct on the Investigation of the Cause of Death [Laki kuolemansyyn selvitt\u00e4misest\u00e4] \u201d 459\/1973 accessed August 17 2026 https:\/\/www.finlex.fi\/en\/legislation\/collection\/1973\/459."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1507"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01191a090"},{"key":"e_1_2_7_12_1","first-page":"25","article-title":"Addiction Liability of I\u2010C\u201026","volume":"1","author":"Wolbach A. 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