{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:39:26Z","timestamp":1791164366745,"version":"4.1.0"},"reference-count":120,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,4,3]],"date-time":"2002-04-03T00:00:00Z","timestamp":1017792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hindbrain is responsible for controlling essential functions such as respiration and heart beat that we literally do not think about most of the time. In addition, cranial nerves projecting from the hindbrain control muscles in the jaw, eye, and face, and receive sensory input from these same areas. In all vertebrates that have been studied, the hindbrain passes through a segmented phase shortly after the neural tube has formed, with a series of seven bulges\u2014the rhombomeres\u2014forming along the anterior\u2010posterior extent of the neural tube. Our current understanding of vertebrate hindbrain development comes from integrating data from several model systems. Work on the chick has helped us to understand the cell biology of the rhombomeres, whereas the power of mouse molecular genetics has allowed investigation of the molecular mechanisms underlying their development. This review focuses on the special insights that the zebrafish system has provided to our understanding of hindbrain development. As we will discuss, work in the zebrafish has elucidated inductive events that specify the presumptive hindbrain domain and has identified genes required for hindbrain segmentation and the specification of segment identities. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.10086","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:24:15Z","timestamp":1030303455000},"page":"1-17","source":"Crossref","is-referenced-by-count":202,"title":["Constructing the hindbrain: Insights from the zebrafish"],"prefix":"10.1002","volume":"224","author":[{"given":"Cecilia B.","family":"Moens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria E.","family":"Prince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1242\/dev.122.3.735","article-title":"Ectopic expression of hoxa1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid\u2010induced phenotype","volume":"122","author":"Alexandre D","year":"1996","journal-title":"Development"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90616-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5394.1711"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng583"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1242\/dev.118.1.139","article-title":"Anterior mesendoderm induces mouse Engrailed genes in explant cultures","volume":"118","author":"Ang SL","year":"1993","journal-title":"Development"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00144-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.16.3081"},{"key":"e_1_2_9_9_1","first-page":"4165","article-title":"spg\/pou2 and mid\u2010\/hindbrain boundary formation","volume":"128","author":"Belting H\u2010G","year":"2001","journal-title":"Development"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.123.1.179"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5306.1640"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1242\/dev.129.4.905","article-title":"The zebrafish spiel\u2010ohne\u2010grenzen (spg) gene encodes a POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre\u2010gastrula morphogenesis","volume":"129","author":"Burgess S","year":"2002","journal-title":"Development"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1242\/dev.124.13.2633","article-title":"Development of branchiomotor neurons in zebra fish","volume":"124","author":"Chandrasekhar A","year":"1997","journal-title":"Development"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1242\/dev.129.3.585","article-title":"Meis family proteins are required for hindbrain development in the zebrafish","volume":"129","author":"Choe S\u2010K","year":"2002","journal-title":"Development"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.118.1.151"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.4.571"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02134-3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90033-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/35042039"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.18.3571"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.7.1427"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00469-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0269"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.117.3.925"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.24.5297"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00100-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90619-2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000147530"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/34848"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80513-9"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/35001077"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.9.2983"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81112-5"},{"key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1242\/dev.112.1.221","article-title":"Formation and regeneration of rhombomere boundaries in the developing chick hindbrain","volume":"112","author":"Guthrie S","year":"1991","journal-title":"Development"},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1242\/dev.118.2.527","article-title":"Selective dispersal of avian rhombomere cells in orthotopic and heterotopic grafts","volume":"118","author":"Guthrie S","year":"1993","journal-title":"Development"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.9.1953"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1242\/dev.103.1.49","article-title":"Segmental pattern of development of the hindbrain and spinal cord of the zebrafish embryo","volume":"103","author":"Hanneman E","year":"1988","journal-title":"Development"},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","DOI":"10.1242\/dev.129.7.1645","article-title":"spiel\u2010ohne\u2010grenzen\/pou2 is an essential regulator of hindbrain segmentation","author":"Hauptmann G","year":"2002","journal-title":"Development"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.194301"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-01-00206.2000"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/383722a0"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1242\/dev.127.1.177","article-title":"Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression","volume":"127","author":"Irving C","year":"2000","journal-title":"Development"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9630"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/35038097"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902330306"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.108.4.581"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80441-2"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00585-1"},{"key":"e_1_2_9_49_1","first-page":"551","article-title":"Regional cell movement and tissue patterning in the zebrafish embryo revealed by fate mapping with caged fluorescein. Biochem","volume":"75","author":"Kozlowski DJ","year":"1997","journal-title":"Cell Biol"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00007-7"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/276565a0"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.869"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90144-Y"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/337424a0"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.113.4.1281"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5290.1109"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(98)80113-5"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/387191a0"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.4.759"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9318"},{"key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1242\/dev.127.22.4925","article-title":"Hindbrain patterning: FGFs regulate Krox\u201020 and mafB\/kr expression in the otic\/preotic region","volume":"127","author":"Marin F","year":"2000","journal-title":"Development"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/35078535"},{"key":"e_1_2_9_62_2","doi-asserted-by":"crossref","DOI":"10.1242\/dev.129.10.2339","article-title":"Knock\u2010down of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention.","author":"McClintock JM","year":"2002","journal-title":"Development"},{"key":"e_1_2_9_63_1","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1242\/dev.128.13.2471","article-title":"Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes","volume":"128","author":"McClintock JM","year":"2001","journal-title":"Development"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90471-N"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(97)00160-3"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.8.2199"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902510203"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902510204"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902510202"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.12.3981"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.3.381"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199810)20:10<794::AID-BIES4>3.0.CO;2-E"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80366-9"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00041-7"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/79951"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401200102"},{"key":"e_1_2_9_77_1","first-page":"1","article-title":"The epigenetic nature of early chordate development","volume":"16","author":"Nieuwkoop PD","year":"1985","journal-title":"Dev Cell Biol"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.5.1087"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0297"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00027-7"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.8500"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.3.393"},{"key":"e_1_2_9_83_1","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1242\/dev.125.13.2381","article-title":"Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain\u2010hindbrain boundary and somitogenesis","volume":"125","author":"Reifers F","year":"1998","journal-title":"Development"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.4.917"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00171-9"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90620-6"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1119"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.8445"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.16.3407"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00209-4"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000126"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.123.1.165"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.3.483"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9997"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.4.1313"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00284-2"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(96)80026-8"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00280-5"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/384630a0"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad946701"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(01)02318-6"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.3.443"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000200"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000051"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90194-K"},{"key":"e_1_2_9_106_1","first-page":"1","article-title":"The segmentation of the primitive neural tube in chick embryos (Gallus domesticus)","volume":"41","author":"Vaage S","year":"1969","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.20.3877"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200001)217:1<109::AID-DVDY10>3.0.CO;2-8"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.8.1299"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.21.4139"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.20.4395"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1997.0642"},{"key":"e_1_2_9_113_1","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1242\/dev.121.8.2595","article-title":"Order and coherence in the fate map of the zebrafish nervous system","volume":"121","author":"Woo K","year":"1995","journal-title":"Development"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5323.254"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8870"},{"key":"e_1_2_9_116_1","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1242\/dev.121.12.4005","article-title":"Expression of truncated Sek\u20101 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain","volume":"121","author":"Xu Q","year":"1995","journal-title":"Development"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/20452"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00299-4"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70255-6"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.10086","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.10086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:45:32Z","timestamp":1760402732000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.10086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,3]]},"references-count":120,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1002\/dvdy.10086"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.10086","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,3]]}}}