{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:35:07Z","timestamp":1791200107201,"version":"4.2.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,5,6]],"date-time":"2002-05-06T00:00:00Z","timestamp":1020643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["Fu 188\/2-2"],"award-info":[{"award-number":["Fu 188\/2-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["Fu 188\/7-1"],"award-info":[{"award-number":["Fu 188\/7-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["Ha 1082\/12-2"],"award-info":[{"award-number":["Ha 1082\/12-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been shown previously that abnormal placental growth occurs in crosses and backcrosses between different mouse (<jats:italic>Mus<\/jats:italic>) species. In such crosses, late gestation placentas may weigh between 13 and 848 mg compared with a mean placental weight of approximately 100 mg in late gestation <jats:italic>M. musculus<\/jats:italic> intraspecific crosses. A locus on the X\u2010chromosome was shown to segregate with placental dysplasia. Thus in the (<jats:italic>M. musculus<\/jats:italic> \u00d7 <jats:italic>M. spretus<\/jats:italic>)F1 \u00d7 <jats:italic>M. musculus<\/jats:italic> backcross, placental hyperplasia cosegregates with a <jats:italic>M. spretus<\/jats:italic> derived X\u2010chromosome. Here we have investigated whether increased cell proliferation and aberrant expression of two genes that are involved in placental growth control, <jats:italic>Igf2<\/jats:italic> and <jats:italic>Esx1<\/jats:italic>, may cause, or contribute to placental hyperplasia. Increased bromodeoxyuridine labeling of nuclei, reflecting enhanced proliferation, was indeed observed in hyperplastic placentas when compared with normal littermate placentas. Also, increased expression of <jats:italic>Igf2<\/jats:italic> was seen in giant cells and spongiotrophoblast. However, when <jats:italic>M. musculus<\/jats:italic> \u00d7 <jats:italic>M. spretus<\/jats:italic> F1 females were backcrossed with males that were heterozygous for a targeted mutation of the <jats:italic>Igf2<\/jats:italic> gene, placentas that carried a <jats:italic>M. spretus<\/jats:italic> derived X\u2010chromosome and were negative for a functional <jats:italic>Igf2<\/jats:italic> allele exhibited an intermediate placental phenotype. Furthermore, in early developmental stages of placental hyperplasia, we observed a decreased expression of the X\u2010chromosomal <jats:italic>Esx1<\/jats:italic> gene. This finding suggests that abnormal expression of both <jats:italic>Igf2<\/jats:italic> and <jats:italic>Esx1<\/jats:italic> contributes to abnormal placental development in mouse interspecific hybrids. However, <jats:italic>Esx1<\/jats:italic> is not regulated by IGF2. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.10094","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:48:25Z","timestamp":1030304905000},"page":"125-134","source":"Crossref","is-referenced-by-count":31,"title":["Proliferation and growth factor expression in abnormally enlarged placentas of mouse interspecific hybrids"],"prefix":"10.1002","volume":"224","author":[{"given":"Ulrich","family":"Zechner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Hemberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Const\u00e2ncia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Orth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Dragatsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"L\u00fcttges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Hameister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinald","family":"Fundele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,5,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.3.839"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80085-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.146.1.255"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199911)216:3<257::AID-DVDY4>3.0.CO;2-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6302"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2795(199907)53:3<294::AID-MRD5>3.0.CO;2-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/345078a0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90513-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/153.1.383"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1242\/dev.116.1.95","article-title":"Parthenogenetic 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